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LYPD1 LY6/PLAUR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 116372, updated on 7-Jun-2020

Summary

Official Symbol
LYPD1provided by HGNC
Official Full Name
LY6/PLAUR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28431
See related
Ensembl:ENSG00000150551 MIM:610450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHTS; LYPDC1
Expression
Broad expression in brain (RPKM 4.3), colon (RPKM 1.3) and 16 other tissues See more
Orthologs

Genomic context

See LYPD1 in Genome Data Viewer
Location:
2q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (132643286..132671526, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (133402337..133429070, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 39 Neighboring gene RN7SK pseudogene 103 Neighboring gene Y-box binding protein 1 pseudogene 7 Neighboring gene uncharacterized LOC105373623 Neighboring gene NCK associated protein 5 Neighboring gene Sharpr-MPRA regulatory region 3189 Neighboring gene NCKAP5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41033, MGC29643

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
 
acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 1
Names
putative HeLa tumor suppressor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077427.4NP_001070895.1  ly6/PLAUR domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_001070895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. This results in translation initiation at a downstream AUG and a protein (isoform b) with a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC079773, AK094501, AK309668, AW014835
    Consensus CDS
    CCDS46416.1
    UniProtKB/Swiss-Prot
    Q8N2G4
    Related
    ENSP00000340563.6, ENST00000345008.6
  2. NM_001321234.2NP_001308163.1  ly6/PLAUR domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC079773, AK130005, AW014835
    UniProtKB/Swiss-Prot
    Q8N2G4
  3. NM_001321235.2NP_001308164.1  ly6/PLAUR domain-containing protein 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC010974, AC079773, AW014835, BP276862
    Consensus CDS
    CCDS46416.1
    UniProtKB/Swiss-Prot
    Q8N2G4
  4. NM_144586.7NP_653187.3  ly6/PLAUR domain-containing protein 1 isoform a precursor

    See identical proteins and their annotated locations for NP_653187.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AC010974, AC079773, AW014835, BC017318
    Consensus CDS
    CCDS42759.1
    UniProtKB/Swiss-Prot
    Q8N2G4
    Related
    ENSP00000380605.2, ENST00000397463.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    132643286..132671526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510546.3XP_011508848.1  ly6/PLAUR domain-containing protein 1 isoform X1

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