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SLC26A8 solute carrier family 26 member 8 [ Homo sapiens (human) ]

Gene ID: 116369, updated on 2-Oct-2018

Summary

Official Symbol
SLC26A8provided by HGNC
Official Full Name
solute carrier family 26 member 8provided by HGNC
Primary source
HGNC:HGNC:14468
See related
Ensembl:ENSG00000112053 MIM:608480; Vega:OTTHUMG00000014586
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAT1; SPGF3
Summary
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
Expression
Restricted expression toward testis (RPKM 27.9) See more
Orthologs

Genomic context

See SLC26A8 in Genome Data Viewer
Location:
6p21.31
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (35943514..36024636, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (35911291..35992413, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC105375035 Neighboring gene uncharacterized LOC105375034 Neighboring gene divergent-paired related homeobox pseudogene 2 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene ADP-sugar pyrophosphatase pseudogene Neighboring gene mitogen-activated protein kinase 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anion transport IDA
Inferred from Direct Assay
more info
PubMed 
bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm capacitation IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testis anion transporter 1
Names
anion transporter/exchanger-8
solute carrier family 26 (anion exchanger), member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033897.1 RefSeqGene

    Range
    5001..86123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193476.1NP_001180405.1  testis anion transporter 1 isoform a

    See identical proteins and their annotated locations for NP_001180405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AF331522, AK122928, AL133507
    Consensus CDS
    CCDS4813.1
    UniProtKB/Swiss-Prot
    Q96RN1
    UniProtKB/TrEMBL
    A0A024RCV0
    Related
    ENSP00000347778.2, OTTHUMP00000215704, ENST00000355574.6, OTTHUMT00000356008
    Conserved Domains (3) summary
    cd07042
    Location:719776
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:92493
    Sulfate_transp; Sulfate permease family
    cl00604
    Location:544584
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
  2. NM_052961.3NP_443193.1  testis anion transporter 1 isoform a

    See identical proteins and their annotated locations for NP_443193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AF331522, AL133507, Z95152
    Consensus CDS
    CCDS4813.1
    UniProtKB/Swiss-Prot
    Q96RN1
    UniProtKB/TrEMBL
    A0A024RCV0
    Related
    ENSP00000417638.1, OTTHUMP00000016279, ENST00000490799.5, OTTHUMT00000040325
    Conserved Domains (3) summary
    cd07042
    Location:719776
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:92493
    Sulfate_transp; Sulfate permease family
    cl00604
    Location:544584
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
  3. NM_138718.2NP_619732.2  testis anion transporter 1 isoform b

    See identical proteins and their annotated locations for NP_619732.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AL133507, BC025408, Z95152
    Consensus CDS
    CCDS4814.1
    UniProtKB/Swiss-Prot
    Q96RN1
    Related
    ENSP00000378100.2, OTTHUMP00000215705, ENST00000394602.6, OTTHUMT00000356009
    Conserved Domains (3) summary
    cd07042
    Location:614671
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:92388
    Sulfate_transp; Sulfate permease family
    cl00604
    Location:439479
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    35943514..36024636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514294.3XP_011512596.1  testis anion transporter 1 isoform X2

    Conserved Domains (3) summary
    cd07042
    Location:693750
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:92467
    Sulfate_transp; Sulfate permease family
    cl00604
    Location:518558
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors
  2. XM_017010235.1XP_016865724.1  testis anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96RN1
    UniProtKB/TrEMBL
    A0A024RCV0
    Conserved Domains (3) summary
    cd07042
    Location:719776
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:92493
    Sulfate_transp; Sulfate permease family
    cl00604
    Location:544584
    STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

RNA

  1. XR_926055.3 RNA Sequence

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