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Aicda activation-induced cytidine deaminase [ Mus musculus (house mouse) ]

Gene ID: 11628, updated on 15-Nov-2022

Summary

Official Symbol
Aicdaprovided by MGI
Official Full Name
activation-induced cytidine deaminaseprovided by MGI
Primary source
MGI:MGI:1342279
See related
Ensembl:ENSMUSG00000040627 AllianceGenome:MGI:1342279
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aid; Arp2
Summary
Enables cytidine deaminase activity. Involved in cytidine deamination and isotype switching. Acts upstream of or within cellular response to lipopolysaccharide and defense response to bacterium. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Is expressed in several structures, including immune system; lower urogenital tract; lung; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Aicda in Genome Data Viewer
Location:
6; 6 F1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122530768..122541139)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122553809..122564180)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene microfibrillar associated protein 5 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytidine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytidine deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables deoxycytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytidine deamination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytidine to uridine editing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in isotype switching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transposition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of nuclear cell cycle DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic diversification of immunoglobulins ISO
Inferred from Sequence Orthology
more info
 
involved_in somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
single-stranded DNA cytosine deaminase
Names
activation induced deaminase
cytidine aminohydrolase
NP_033775.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009645.2NP_033775.1  single-stranded DNA cytosine deaminase

    See identical proteins and their annotated locations for NP_033775.1

    Status: VALIDATED

    Source sequence(s)
    AF132979, BB221671, CJ161825
    Consensus CDS
    CCDS20497.1
    UniProtKB/Swiss-Prot
    Q9WVE0
    UniProtKB/TrEMBL
    A0A8C6IB96
    Related
    ENSMUSP00000040524.8, ENSMUST00000043301.14
    Conserved Domains (3) summary
    cd01283
    Location:5129
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:124165
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:11178
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122530768..122541139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)