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MOGAT1 monoacylglycerol O-acyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 116255, updated on 25-Nov-2021

Summary

Official Symbol
MOGAT1provided by HGNC
Official Full Name
monoacylglycerol O-acyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:18210
See related
Ensembl:ENSG00000124003 MIM:610268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MGAT1; DGAT2L; DGAT2L1
Summary
Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in gall bladder (RPKM 7.8) and fat (RPKM 0.6) See more
Orthologs
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Genomic context

See MOGAT1 in Genome Data Viewer
Location:
2q36.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (222671658..222709930)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223536377..223574649)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 49 Neighboring gene phenylalanyl-tRNA synthetase subunit beta Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene uncharacterized LOC105373902 Neighboring gene RRAS2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory regions 6546 and 9925 Neighboring gene Sharpr-MPRA regulatory region 7025 Neighboring gene ribosomal protein L31 pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of monoacylglycerol O-acyltransferase 1 (MOGAT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2-acylglycerol O-acyltransferase activity TAS
Traceable Author Statement
more info
 
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables diacylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in diacylglycerol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
2-acylglycerol O-acyltransferase 1
Names
acyl-CoA:monoacylglycerol acyltransferase 1
diacylglycerol O-acyltransferase 2 like 1
diacylglycerol O-acyltransferase candidate 2
diacylglycerol acyltransferase 2-like protein 1
hDC2
NP_477513.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058165.3NP_477513.2  2-acylglycerol O-acyltransferase 1

    See identical proteins and their annotated locations for NP_477513.2

    Status: VALIDATED

    Source sequence(s)
    AC104772, AF384163, BN000154
    Consensus CDS
    CCDS46524.1
    UniProtKB/Swiss-Prot
    Q96PD6
    Related
    ENSP00000406674.3, ENST00000446656.4
    Conserved Domains (1) summary
    cl17185
    Location:48335
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    222671658..222709930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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