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Ahsg alpha-2-HS-glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 11625, updated on 12-Aug-2019

Summary

Official Symbol
Ahsgprovided by MGI
Official Full Name
alpha-2-HS-glycoproteinprovided by MGI
Primary source
MGI:MGI:107189
See related
Ensembl:ENSMUSG00000022868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Biased expression in liver E18 (RPKM 13022.2), liver adult (RPKM 6468.6) and 1 other tissue See more
Orthologs

Genomic context

See Ahsg in Genome Data Viewer
Location:
16 B1; 16 13.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22892015..22899451)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (22892115..22899511)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene TBCC domain containing 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene predicted gene, 30505 Neighboring gene predicted gene, 30611 Neighboring gene fetuin beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acute-phase response ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
ossification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-2-HS-glycoprotein
Names
countertrypin
fetuin-A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276449.1NP_001263378.1  alpha-2-HS-glycoprotein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AI098804, AI158912, BY757844, BY776421
    Conserved Domains (1) summary
    smart00043
    Location:2696
    CY; Cystatin-like domain
  2. NM_001276450.1NP_001263379.1  alpha-2-HS-glycoprotein isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AI158912, AK149474, BY776421, CT027991
    UniProtKB/TrEMBL
    Q3UEK9
    Conserved Domains (2) summary
    smart00043
    Location:26126
    CY; Cystatin-like domain
    pfam00031
    Location:142232
    Cystatin; Cystatin domain
  3. NM_013465.2NP_038493.1  alpha-2-HS-glycoprotein isoform 1 precursor

    See identical proteins and their annotated locations for NP_038493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI158912, AK149474, BY776421
    Consensus CDS
    CCDS28071.1
    UniProtKB/Swiss-Prot
    P29699
    UniProtKB/TrEMBL
    Q3UEK9
    Related
    ENSMUSP00000023583.5, ENSMUST00000023583.6
    Conserved Domains (2) summary
    smart00043
    Location:26133
    CY; Cystatin-like domain
    pfam00031
    Location:149239
    Cystatin; Cystatin domain

RNA

  1. NR_075099.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA217823, AI158912, BY757844, BY768303, BY776421, CT027991
    Related
    ENSMUST00000232098.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p6 C57BL/6J

    Range
    22892015..22899451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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