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Ahr aryl-hydrocarbon receptor [ Mus musculus (house mouse) ]

Gene ID: 11622, updated on 30-Nov-2021

Summary

Official Symbol
Ahrprovided by MGI
Official Full Name
aryl-hydrocarbon receptorprovided by MGI
Primary source
MGI:MGI:105043
See related
Ensembl:ENSMUSG00000019256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ah; In; Ahh; Ahre; bHLHe76
Summary
The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung adult (RPKM 15.1), bladder adult (RPKM 5.5) and 18 other tissues See more
Orthologs
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Genomic context

See Ahr in Genome Data Viewer
Location:
12 A3; 12 15.78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (35547978..35584988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (35497979..35534989, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (36182651..36219661, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 680-3 Neighboring gene predicted gene, 26071 Neighboring gene RIKEN cDNA 9130015A21 gene Neighboring gene predicted gene, 40388

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables aryl hydrocarbon receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in B-1 B cell homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel diameter maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to 2,3,7,8-tetrachlorodibenzodioxine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to 3-methylcholanthrene IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circumferential growth involved in left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in common bile duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerulus morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in kidney morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell mediated immune response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of growth rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart growth TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reproductive structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in venous blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of aryl hydrocarbon receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of aryl hydrocarbon receptor complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic aryl hydrocarbon receptor complex TAS
Traceable Author Statement
more info
PubMed 
part_of nuclear aryl hydrocarbon receptor complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
aryl hydrocarbon receptor
Names
ah receptor
dioxin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314027.1NP_001300956.1  aryl hydrocarbon receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK153678, AY662081
    UniProtKB/TrEMBL
    Q3U5D9
    Conserved Domains (2) summary
    cd00130
    Location:360
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:174259
    PAS_3; PAS fold
  2. NM_013464.4NP_038492.1  aryl hydrocarbon receptor isoform 1

    See identical proteins and their annotated locations for NP_038492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK153678
    Consensus CDS
    CCDS36434.1
    UniProtKB/Swiss-Prot
    P30561
    UniProtKB/TrEMBL
    Q3U5D9
    Related
    ENSMUSP00000112137.3, ENSMUST00000116436.9
    Conserved Domains (5) summary
    smart00091
    Location:111177
    PAS; PAS domain
    cd00083
    Location:3677
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:276380
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00989
    Location:111177
    PAS; PAS fold
    pfam08447
    Location:291376
    PAS_3; PAS fold

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    35547978..35584988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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