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TM4SF19 transmembrane 4 L six family member 19 [ Homo sapiens (human) ]

Gene ID: 116211, updated on 23-Nov-2021

Summary

Official Symbol
TM4SF19provided by HGNC
Official Full Name
transmembrane 4 L six family member 19provided by HGNC
Primary source
HGNC:HGNC:25167
See related
Ensembl:ENSG00000145107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCTM4
Summary
The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Expression
Biased expression in testis (RPKM 3.1), esophagus (RPKM 0.9) and 10 other tissues See more
Orthologs
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Genomic context

See TM4SF19 in Genome Data Viewer
Location:
3q29
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (196323547..196338388, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196050418..196065259, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphate cytidylyltransferase 1A, choline Neighboring gene dynein light chain Tctex-type 2B Neighboring gene TM4SF19-DYNLT2B readthrough (NMD candidate) Neighboring gene uncharacterized LOC107986031 Neighboring gene TM4SF19 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 3422 Neighboring gene RNA, U6 small nuclear 910, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Readthrough TM4SF19-DYNLT2B

Readthrough gene: TM4SF19-DYNLT2B, Included gene: DYNLT2B

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane 4 L6 family member 19
Names
osteoclast maturation-associated gene 4 protein
tetraspan membrane protein OCTM4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054731.1 RefSeqGene

    Range
    5033..19874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204897.2NP_001191826.1  transmembrane 4 L6 family member 19 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    BC171824, BP396791, CA430273, CA489370
    Conserved Domains (1) summary
    pfam05805
    Location:11149
    L6_membrane; L6 membrane protein
  2. NM_001204898.2NP_001191827.1  transmembrane 4 L6 family member 19 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AC069257, AF192910, BC171870, CA430273, CA489370
    Consensus CDS
    CCDS56299.1
    UniProtKB/Swiss-Prot
    Q96DZ7
    UniProtKB/TrEMBL
    B7ZW46
    Related
    ENSP00000387728.1, ENST00000454715.5
    Conserved Domains (1) summary
    pfam05805
    Location:11182
    L6_membrane; L6 membrane protein
  3. NM_138461.4NP_612470.2  transmembrane 4 L6 family member 19 isoform 1

    See identical proteins and their annotated locations for NP_612470.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF192910, BC146985, CA430273, CA489370
    Consensus CDS
    CCDS3316.1
    UniProtKB/Swiss-Prot
    Q96DZ7
    Related
    ENSP00000273695.4, ENST00000273695.4
    Conserved Domains (1) summary
    pfam05805
    Location:11208
    L6_membrane; L6 membrane protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    196323547..196338388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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