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CYYR1 cysteine and tyrosine rich 1 [ Homo sapiens (human) ]

Gene ID: 116159, updated on 23-Nov-2021

Summary

Official Symbol
CYYR1provided by HGNC
Official Full Name
cysteine and tyrosine rich 1provided by HGNC
Primary source
HGNC:HGNC:16274
See related
Ensembl:ENSG00000166265 MIM:616020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C21orf95
Expression
Broad expression in adrenal (RPKM 4.2), fat (RPKM 3.9) and 23 other tissues See more
Orthologs
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Genomic context

See CYYR1 in Genome Data Viewer
Location:
21q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (26466216..26573286, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27838535..27945605, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene myristoylated alanine rich protein kinase C substrate pseudogene 1 Neighboring gene CYYR1 antisense RNA 1 Neighboring gene uncharacterized LOC105372758 Neighboring gene uncharacterized LOC107985474 Neighboring gene uncharacterized LOC105372760 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cysteine and tyrosine-rich protein 1
Names
cysteine/tyrosine-rich 1
proline-rich domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320768.2NP_001307697.2  cysteine and tyrosine-rich protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AF401639, AK054581, AK223576, BX100308, DC382466
    Related
    ENSP00000498505.1, ENST00000652641.2
    Conserved Domains (1) summary
    pfam10873
    Location:7155
    CYYR1; Cysteine and tyrosine-rich protein 1
  2. NM_052954.5NP_443186.3  cysteine and tyrosine-rich protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1
    Source sequence(s)
    AF401639, AK054581, AL833200, DC391430
    Consensus CDS
    CCDS13578.1
    Related
    ENSP00000299340.4, ENST00000299340.9
    Conserved Domains (1) summary
    pfam10873
    Location:7154
    CYYR1; Cysteine and tyrosine-rich protein 1

RNA

  1. NR_135472.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF401639, AK223576, AK304124, AL833200, DC391430

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    26466216..26573286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529450.2XP_011527752.1  cysteine and tyrosine-rich protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10873
    Location:115219
    DUF2668; Protein of unknown function (DUF2668)

RNA

  1. XR_001754806.1 RNA Sequence

  2. XR_001754804.2 RNA Sequence

  3. XR_001754808.1 RNA Sequence

  4. XR_001754809.1 RNA Sequence

  5. XR_001754807.1 RNA Sequence

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