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LRRC3B leucine rich repeat containing 3B [ Homo sapiens (human) ]

Gene ID: 116135, updated on 7-Aug-2021

Summary

Official Symbol
LRRC3Bprovided by HGNC
Official Full Name
leucine rich repeat containing 3Bprovided by HGNC
Primary source
HGNC:HGNC:28105
See related
Ensembl:ENSG00000179796 MIM:618996
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRP15
Summary
The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Biased expression in brain (RPKM 1.4), testis (RPKM 0.6) and 3 other tissues See more
Orthologs
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Genomic context

See LRRC3B in Genome Data Viewer
Location:
3p24.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (26622772..26717301)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (26664263..26752267)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9567 Neighboring gene VENT homeobox pseudogene 4 Neighboring gene LRRC3B antisense RNA 1 Neighboring gene NIMA related kinase 10 Neighboring gene uncharacterized LOC105377004 Neighboring gene MICOS10 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102927, AC114877.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing protein 3B
Names
leucine-rich repeat protein 15
leucine-rich repeat protein LRP15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317808.2NP_001304737.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, AC114877, BC040656, DA414440
    Consensus CDS
    CCDS2644.1
    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  2. NM_001317809.2NP_001304738.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, BC040656, BC067784, BI917966
    Consensus CDS
    CCDS2644.1
    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  3. NM_001317810.3NP_001304739.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, AC114877
    Consensus CDS
    CCDS2644.1
    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Related
    ENSP00000406370.1, ENST00000417744.5
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  4. NM_001317811.2NP_001304740.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, BC087849
    Consensus CDS
    CCDS2644.1
    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Related
    ENSP00000394940.2, ENST00000456208.2
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  5. NM_001395645.1NP_001382574.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, AC114877
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  6. NM_001395646.1NP_001382575.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, AC114877
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  7. NM_001395647.1NP_001382576.1  leucine-rich repeat-containing protein 3B precursor

    Status: REVIEWED

    Source sequence(s)
    AC099754, AC114877
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  8. NM_052953.4NP_443185.1  leucine-rich repeat-containing protein 3B precursor

    See identical proteins and their annotated locations for NP_443185.1

    Status: REVIEWED

    Source sequence(s)
    AC099754, BC040656, BC067784
    Consensus CDS
    CCDS2644.1
    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Related
    ENSP00000379880.2, ENST00000396641.6
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    26622772..26717301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264850.4XP_005264907.1  leucine-rich repeat-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Related
    ENSP00000497471.1, ENST00000648296.1
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  2. XM_017005675.1XP_016861164.1  leucine-rich repeat-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  3. XM_005264849.3XP_005264906.1  leucine-rich repeat-containing protein 3B isoform X1

    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat
  4. XM_011533332.3XP_011531634.1  leucine-rich repeat-containing protein 3B isoform X1

    See identical proteins and their annotated locations for XP_011531634.1

    UniProtKB/Swiss-Prot
    Q96PB8
    UniProtKB/TrEMBL
    A0A024R2R0
    Conserved Domains (3) summary
    smart00013
    Location:3368
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:6689
    LRR_1; leucine-rich repeat [structural motif]
    pfam13855
    Location:69125
    LRR_8; Leucine rich repeat

RNA

  1. XR_001739999.1 RNA Sequence

  2. XR_001739998.1 RNA Sequence

  3. XR_001739997.1 RNA Sequence

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