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DNTTIP1 deoxynucleotidyltransferase terminal interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 116092, updated on 7-Jul-2019

Summary

Official Symbol
DNTTIP1provided by HGNC
Official Full Name
deoxynucleotidyltransferase terminal interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16160
See related
Ensembl:ENSG00000101457 MIM:611388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Tdif1; C20orf167; dJ447F3.4
Summary
DNTTIP1 binds DNA and enhances the activity of terminal deoxynucleotidyltransferase (TDT, or DNTT; MIM 187410), a DNA polymerase that catalyzes the polymerization of DNA in the absence of a DNA template (Yamashita et al., 2001 [PubMed 11473582]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 14.1), bone marrow (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See DNTTIP1 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (45791954..45811419)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44420576..44440066)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 3 Neighboring gene serine peptidase inhibitor, Kunitz type 5, pseudogene Neighboring gene RNA, U6atac small nuclear 38, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 C Neighboring gene troponin C2, fast skeletal type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
deoxynucleotidyltransferase terminal-interacting protein 1
Names
TdT binding protein
tdT-interacting factor 1
terminal deoxynucleotidyltransferase-interacting factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052951.3NP_443183.1  deoxynucleotidyltransferase terminal-interacting protein 1

    See identical proteins and their annotated locations for NP_443183.1

    Status: VALIDATED

    Source sequence(s)
    AB035676, BG720866
    Consensus CDS
    CCDS13369.1
    UniProtKB/Swiss-Prot
    Q9H147
    Related
    ENSP00000361705.3, ENST00000372622.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    45791954..45811419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451823.1XP_024307591.1  deoxynucleotidyltransferase terminal-interacting protein 1 isoform X1

    Related
    ENSP00000400573.1, ENST00000435014.1
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