Format

Send to:

Choose Destination

LRRC58 leucine rich repeat containing 58 [ Homo sapiens (human) ]

Gene ID: 116064, updated on 5-Jul-2020

Summary

Official Symbol
LRRC58provided by HGNC
Official Full Name
leucine rich repeat containing 58provided by HGNC
Primary source
HGNC:HGNC:26968
See related
Ensembl:ENSG00000163428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in adrenal (RPKM 14.9), thyroid (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See LRRC58 in Genome Data Viewer
Location:
3q13.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (120324509..120349354, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (120043576..120068186, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374065 Neighboring gene G protein-coupled receptor 156 Neighboring gene PTOV1, extended AT-hook containing adaptor protein pseudogene Neighboring gene uncharacterized LOC100130701 Neighboring gene microRNA 198 Neighboring gene follistatin like 1 Neighboring gene cyclin-dependent kinase 2-associated protein 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
leucine-rich repeat-containing protein 58

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099678.2NP_001093148.1  leucine-rich repeat-containing protein 58

    See identical proteins and their annotated locations for NP_001093148.1

    Status: VALIDATED

    Source sequence(s)
    AC063952, BC013757
    Consensus CDS
    CCDS46892.1
    UniProtKB/Swiss-Prot
    Q96CX6
    Related
    ENSP00000295628.3, ENST00000295628.4
    Conserved Domains (4) summary
    cd00116
    Location:59179
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:7092
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:189228
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:167224
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    120324509..120349354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center