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RNF166 ring finger protein 166 [ Homo sapiens (human) ]

Gene ID: 115992, updated on 7-Jun-2020

Summary

Official Symbol
RNF166provided by HGNC
Official Full Name
ring finger protein 166provided by HGNC
Primary source
HGNC:HGNC:28856
See related
Ensembl:ENSG00000158717 MIM:617178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 9.1) and 23 other tissues See more
Orthologs

Genomic context

See RNF166 in Genome Data Viewer
Location:
16q24.2-q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (88696499..88706421, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (88762903..88772829, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mevalonate diphosphate decarboxylase Neighboring gene SNAI3 antisense RNA 1 Neighboring gene snail family transcriptional repressor 3 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene microRNA 4722 Neighboring gene piezo type mechanosensitive ion channel component 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity?
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2647, MGC14381

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF166
Names
RING-type E3 ubiquitin transferase RNF166
NP_001165286.1
NP_001165287.1
NP_849163.1
XP_011521147.1
XP_011521148.1
XP_011521149.1
XP_016878399.1
XP_016878401.1
XP_016878402.1
XP_024305915.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171815.2NP_001165286.1  E3 ubiquitin-protein ligase RNF166 isoform 2

    See identical proteins and their annotated locations for NP_001165286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS54057.1
    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000457336.1, ENST00000567844.1
    Conserved Domains (1) summary
    pfam05605
    Location:68127
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  2. NM_001171816.2NP_001165287.1  E3 ubiquitin-protein ligase RNF166 isoform 3

    See identical proteins and their annotated locations for NP_001165287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS54056.1
    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000440454.2, ENST00000541206.6
    Conserved Domains (1) summary
    pfam05605
    Location:4099
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  3. NM_178841.4NP_849163.1  E3 ubiquitin-protein ligase RNF166 isoform 1

    See identical proteins and their annotated locations for NP_849163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC138028
    Consensus CDS
    CCDS10969.1
    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000326095.4, ENST00000312838.9
    Conserved Domains (2) summary
    pfam05605
    Location:149208
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    cd16549
    Location:3076
    RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    88696499..88706421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522846.1XP_011521148.1  E3 ubiquitin-protein ligase RNF166 isoform X3

    Conserved Domains (2) summary
    cd00162
    Location:3276
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05605
    Location:149208
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  2. XM_011522845.2XP_011521147.1  E3 ubiquitin-protein ligase RNF166 isoform X2

    Conserved Domains (1) summary
    cd00162
    Location:3276
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_024450147.1XP_024305915.1  E3 ubiquitin-protein ligase RNF166 isoform X5

    Conserved Domains (1) summary
    pfam05605
    Location:4099
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  4. XM_017022910.2XP_016878399.1  E3 ubiquitin-protein ligase RNF166 isoform X1

  5. XM_017022913.2XP_016878402.1  E3 ubiquitin-protein ligase RNF166 isoform X5

    UniProtKB/Swiss-Prot
    Q96A37
    Related
    ENSP00000446301.2, ENST00000537718.6
    Conserved Domains (1) summary
    pfam05605
    Location:4099
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  6. XM_011522847.1XP_011521149.1  E3 ubiquitin-protein ligase RNF166 isoform X6

    Conserved Domains (1) summary
    pfam05605
    Location:4099
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  7. XM_017022912.1XP_016878401.1  E3 ubiquitin-protein ligase RNF166 isoform X4

    Conserved Domains (1) summary
    cd00162
    Location:3276
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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