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ODAD3 outer dynein arm docking complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 115948, updated on 23-Nov-2021

Summary

Official Symbol
ODAD3provided by HGNC
Official Full Name
outer dynein arm docking complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:28303
See related
Ensembl:ENSG00000198003 MIM:615956
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODA10; CILD30; CCDC151
Summary
This gene encodes a protein containing coiled-coil domains. The encoded protein functions in outer dynein arm assembly and is required for motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Broad expression in testis (RPKM 5.1), lung (RPKM 1.6) and 24 other tissues See more
Orthologs
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Genomic context

See ODAD3 in Genome Data Viewer
Location:
19p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (11420605..11435782, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11531273..11546603, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene erythropoietin receptor Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene protein kinase C substrate 80K-H Neighboring gene ELAV like RNA binding protein 3 Neighboring gene zinc finger protein 653 Neighboring gene microRNA 7974

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31801, MGC20983

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outer dynein arm assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
outer dynein arm-docking complex subunit 3
Names
coiled-coil domain containing 151
coiled-coil domain-containing protein 151

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_041777.1 RefSeqGene

    Range
    5662..20178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001302453.1NP_001289382.1  outer dynein arm-docking complex subunit 3 isoform 2

    See identical proteins and their annotated locations for NP_001289382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK302113
    UniProtKB/Swiss-Prot
    A5D8V7
    Conserved Domains (1) summary
    TIGR02168
    Location:90419
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  2. NM_001302454.2NP_001289383.1  outer dynein arm-docking complex subunit 3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several exons in the coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AC008481, AK308072
    Consensus CDS
    CCDS77237.1
    UniProtKB/TrEMBL
    K7EN59
    Related
    ENSP00000466800.1, ENST00000591179.5
    Conserved Domains (1) summary
    TIGR02168
    Location:131413
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  3. NM_145045.5NP_659482.3  outer dynein arm-docking complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_659482.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK056363, BC036041, DB040667
    Consensus CDS
    CCDS42501.1
    UniProtKB/Swiss-Prot
    A5D8V7
    UniProtKB/TrEMBL
    B3KPH7
    Related
    ENSP00000348757.3, ENST00000356392.9
    Conserved Domains (1) summary
    TIGR02168
    Location:144473
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    11420605..11435782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026241.1XP_016881730.1  outer dynein arm-docking complex subunit 3 isoform X1

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