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Aga aspartylglucosaminidase [ Mus musculus (house mouse) ]

Gene ID: 11593, updated on 23-May-2018
Official Symbol
Agaprovided by MGI
Official Full Name
aspartylglucosaminidaseprovided by MGI
Primary source
MGI:MGI:104873
See related
Ensembl:ENSMUSG00000031521 Vega:OTTMUSG00000060612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW060726
Summary
This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 7.4), placenta adult (RPKM 6.8) and 28 other tissues See more
Orthologs
See Aga in Genome Data Viewer
Location:
8; 8 B1.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (53511686..53523422)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (54597080..54608776)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39179 Neighboring gene predicted gene, 39180 Neighboring gene predicted gene, 39181 Neighboring gene nei like 3 (E. coli)

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISO
Inferred from Sequence Orthology
more info
 
asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-aspartyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deglycosylation ISO
Inferred from Sequence Orthology
more info
 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein maturation IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Names
N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
glycosylasparaginase
NP_001005847.1
NP_001191983.1
XP_006509312.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005847.2NP_001005847.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001005847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108413, AW060726, BQ032917, BQ571087, CD541877
    Consensus CDS
    CCDS22304.1
    UniProtKB/Swiss-Prot
    Q64191
    UniProtKB/TrEMBL
    A2RSS6
    Related
    ENSMUSP00000033920.4, OTTMUSP00000077089, ENSMUST00000033920.5, OTTMUST00000148256
    Conserved Domains (1) summary
    cd04513
    Location:29332
    Glycosylasparaginase; Glycosylasparaginase and similar proteins
  2. NM_001205054.1NP_001191983.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC108413, BQ032917
    Consensus CDS
    CCDS85539.1
    UniProtKB/TrEMBL
    B7ZNK6
    Related
    ENSMUSP00000148133.1, OTTMUSP00000077088, ENSMUST00000211424.1, OTTMUST00000148255
    Conserved Domains (1) summary
    cd04513
    Location:29322
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    53511686..53523422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509249.3XP_006509312.2  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1

    Conserved Domains (1) summary
    cd04513
    Location:29313
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RNA

  1. XR_378907.3 RNA Sequence

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