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Aga aspartylglucosaminidase [ Mus musculus (house mouse) ]

Gene ID: 11593, updated on 24-Apr-2022

Summary

Official Symbol
Agaprovided by MGI
Official Full Name
aspartylglucosaminidaseprovided by MGI
Primary source
MGI:MGI:104873
See related
Ensembl:ENSMUSG00000031521 AllianceGenome:MGI:104873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AW060726
Summary
This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 7.4), placenta adult (RPKM 6.8) and 28 other tissues See more
Orthologs
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Genomic context

See Aga in Genome Data Viewer
Location:
8; 8 B1.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (53964718..53976457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (53511683..53523422)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (54597080..54608776)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39180 Neighboring gene predicted gene, 22841 Neighboring gene predicted gene, 39181 Neighboring gene nei like 3 (E. coli) Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in protein deglycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deglycosylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Names
N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
glycosylasparaginase
NP_001005847.1
NP_001191983.1
XP_006509312.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005847.2NP_001005847.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001005847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC108413, AW060726, BQ032917, BQ571087, CD541877
    Consensus CDS
    CCDS22304.1
    UniProtKB/Swiss-Prot
    Q64191
    UniProtKB/TrEMBL
    A2RSS6
    Related
    ENSMUSP00000033920.5, ENSMUST00000033920.6
    Conserved Domains (1) summary
    cd04513
    Location:29332
    Glycosylasparaginase; Glycosylasparaginase and similar proteins
  2. NM_001205054.1NP_001191983.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 2 precursor

    See identical proteins and their annotated locations for NP_001191983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC108413, BQ032917
    Consensus CDS
    CCDS85539.1
    UniProtKB/TrEMBL
    B7ZNK6
    Related
    ENSMUSP00000148133.2, ENSMUST00000211424.2
    Conserved Domains (1) summary
    cd04513
    Location:29322
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    53964718..53976457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509249.4XP_006509312.2  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1

    Conserved Domains (1) summary
    cd04513
    Location:29313
    Glycosylasparaginase; Glycosylasparaginase and similar proteins

RNA

  1. XR_378907.5 RNA Sequence