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CKM creatine kinase, M-type [ Homo sapiens (human) ]

Gene ID: 1158, updated on 23-Nov-2021

Summary

Official Symbol
CKMprovided by HGNC
Official Full Name
creatine kinase, M-typeprovided by HGNC
Primary source
HGNC:HGNC:1994
See related
Ensembl:ENSG00000104879 MIM:123310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKMM; M-CK; CPK-M
Summary
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 751.9), esophagus (RPKM 219.5) and 1 other tissue See more
Orthologs
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Genomic context

See CKM in Genome Data Viewer
Location:
19q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45306413..45322875, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45809671..45826133, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene exocyst complex component 3 like 2 Neighboring gene exocyst complex component 3 like 4 pseudogene Neighboring gene microtubule affinity regulating kinase 4 Neighboring gene heart enhancer 22 Neighboring gene ribosomal protein S16 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
CKM and LILRB5 Are Associated with Serum Levels of Creatine Kinase.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
creatine kinase M-type
Names
creatine kinase M chain
creatine kinase, muscle
creatine phosphokinase M-type
NP_001815.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001824.5NP_001815.2  creatine kinase M-type

    See identical proteins and their annotated locations for NP_001815.2

    Status: REVIEWED

    Source sequence(s)
    AJ572902, AK313281, DA896166
    Consensus CDS
    CCDS12659.1
    UniProtKB/Swiss-Prot
    P06732
    UniProtKB/TrEMBL
    B2R892
    Related
    ENSP00000221476.2, ENST00000221476.4
    Conserved Domains (1) summary
    cd00716
    Location:16373
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45306413..45322875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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