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FANCD2OS FANCD2 opposite strand [ Homo sapiens (human) ]

Gene ID: 115795, updated on 23-Nov-2021

Summary

Official Symbol
FANCD2OSprovided by HGNC
Official Full Name
FANCD2 opposite strandprovided by HGNC
Primary source
HGNC:HGNC:28623
See related
Ensembl:ENSG00000163705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3orf24
Summary
This gene encodes a conserved protein of unknown function. [provided by RefSeq, Jan 2013]
Expression
Biased expression in testis (RPKM 12.7), bone marrow (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

See FANCD2OS in Genome Data Viewer
Location:
3p25.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (10081320..10108603, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (10123004..10149939, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 3p25 FANCD2 Alu-mediated recombination region Neighboring gene FA complementation group D2 Neighboring gene RNA, U6 small nuclear 670, pseudogene Neighboring gene CYCS pseudogene 11 Neighboring gene 3p25 BRK1 Alu-mediated recombination region Neighboring gene BRICK1 subunit of SCAR/WAVE actin nucleating complex Neighboring gene 3p25 von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Alu-mediated recombination region Neighboring gene von Hippel-Lindau tumor suppressor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40179

General protein information

Preferred Names
FANCD2 opposite strand protein
Names
Fanconi anemia group D2 protein opposite strand transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042053.1 RefSeqGene

    Range
    4977..31912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164839.2NP_001158311.1  FANCD2 opposite strand protein

    See identical proteins and their annotated locations for NP_001158311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034193, AF230334, AW074860
    Consensus CDS
    CCDS2596.1
    UniProtKB/Swiss-Prot
    Q96PS1
    Related
    ENSP00000429608.1, ENST00000450660.3
    Conserved Domains (1) summary
    pfam15124
    Location:3177
    FANCD2OS; FANCD2 opposite strand protein
  2. NM_173472.2NP_775743.1  FANCD2 opposite strand protein

    See identical proteins and their annotated locations for NP_775743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC034193, BC028122
    Consensus CDS
    CCDS2596.1
    UniProtKB/Swiss-Prot
    Q96PS1
    Related
    ENSP00000429663.1, ENST00000524279.1
    Conserved Domains (1) summary
    pfam15124
    Location:3177
    FANCD2OS; FANCD2 opposite strand protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    10081320..10108603 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533330.2XP_011531632.1  FANCD2 opposite strand protein isoform X1

    Conserved Domains (1) summary
    pfam15124
    Location:12186
    DUF4563; Domain of unknown function (DUF4563)
  2. XM_011533331.2XP_011531633.1  FANCD2 opposite strand protein isoform X2

    See identical proteins and their annotated locations for XP_011531633.1

    UniProtKB/Swiss-Prot
    Q96PS1
    Conserved Domains (1) summary
    pfam15124
    Location:3177
    FANCD2OS; FANCD2 opposite strand protein
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