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ARL11 ADP ribosylation factor like GTPase 11 [ Homo sapiens (human) ]

Gene ID: 115761, updated on 23-Nov-2021

Summary

Official Symbol
ARL11provided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 11provided by HGNC
Primary source
HGNC:HGNC:24046
See related
Ensembl:ENSG00000152213 MIM:609351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARLTS1
Summary
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
Expression
Broad expression in lymph node (RPKM 2.7), spleen (RPKM 2.1) and 17 other tissues See more
Orthologs
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Genomic context

See ARL11 in Genome Data Viewer
Location:
13q14.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (49628456..49633872)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50202643..50208008)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RCC1 and BTB domain containing protein 1 Neighboring gene uncharacterized LOC105370204 Neighboring gene uncharacterized LOC105370205 Neighboring gene EBP like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of brain lesion distribution in multiple sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33930, MGC17429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 11
Names
ADP-ribosylation factor-like 11
ADP-ribosylation factor-like tumor suppressor gene 1
ADP-ribosylation factor-like tumor suppressor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021342.1 RefSeqGene

    Range
    5209..10574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138450.6NP_612459.1  ADP-ribosylation factor-like protein 11

    See identical proteins and their annotated locations for NP_612459.1

    Status: REVIEWED

    Source sequence(s)
    AF441378, AK091249
    Consensus CDS
    CCDS9419.1
    UniProtKB/Swiss-Prot
    Q969Q4
    Related
    ENSP00000282026.1, ENST00000282026.2
    Conserved Domains (1) summary
    cd04156
    Location:14172
    ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    49628456..49633872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266253.3XP_005266310.1  ADP-ribosylation factor-like protein 11 isoform X1

    See identical proteins and their annotated locations for XP_005266310.1

    UniProtKB/Swiss-Prot
    Q969Q4
    Conserved Domains (1) summary
    cd04156
    Location:14172
    ARLTS1; Arf-like tumor suppressor gene 1 (ARLTS1 or Arl11)
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