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TRMT61A tRNA methyltransferase 61A [ Homo sapiens (human) ]

Gene ID: 115708, updated on 23-Nov-2021

Summary

Official Symbol
TRMT61Aprovided by HGNC
Official Full Name
tRNA methyltransferase 61Aprovided by HGNC
Primary source
HGNC:HGNC:23790
See related
Ensembl:ENSG00000166166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCD14; TRM61; Gcd14p; hTRM61; C14orf172
Expression
Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT61A in Genome Data Viewer
Location:
14q32.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103529196..103537073)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103995533..104003410)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268130 Neighboring gene creatine kinase B Neighboring gene RNA, U7 small nuclear 160 pseudogene Neighboring gene BAG cochaperone 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
tRNA methyltransferase 61 homolog A
tRNA(m1A58)-methyltransferase subunit TRM61
tRNA(m1A58)-methyltransferase subunit TRMT61A
tRNA(m1A58)MTase subunit TRM61
tRNA(m1A58)MTase subunit TRMT61A
NP_689520.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152307.3NP_689520.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_689520.2

    Status: VALIDATED

    Source sequence(s)
    AL133367, AL139300
    Consensus CDS
    CCDS41994.1
    UniProtKB/Swiss-Prot
    Q96FX7
    UniProtKB/TrEMBL
    A0A024R6Q2
    Related
    ENSP00000374399.4, ENST00000389749.9
    Conserved Domains (2) summary
    pfam08704
    Location:64286
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:2358
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103529196..103537073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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