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ARHGAP33 Rho GTPase activating protein 33 [ Homo sapiens (human) ]

Gene ID: 115703, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP33provided by HGNC
Official Full Name
Rho GTPase activating protein 33provided by HGNC
Primary source
HGNC:HGNC:23085
See related
Ensembl:ENSG00000004777 MIM:614902
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX26; TCGAP; NOMA-GAP
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Alternative splice variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Expression
Broad expression in testis (RPKM 7.3), brain (RPKM 5.7) and 23 other tissues See more
Orthologs

Genomic context

See ARHGAP33 in Genome Data Viewer
Location:
19q13.12
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35775515..35788822)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36266417..36279724)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heat shock protein family B (small) member 6 Neighboring gene proline and serine rich 3 Neighboring gene long intergenic non-protein coding RNA 1529 Neighboring gene proline dehydrogenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho GTPase-activating protein 33
Names
neurite outgrowth multiadaptor RhoGAP protein
rho-type GTPase-activating protein 33
sorting nexin 26
tc10/CDC42 GTPase-activating protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172630.2NP_001166101.1  rho GTPase-activating protein 33 isoform 2

    See identical proteins and their annotated locations for NP_001166101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in 5' and 3' coding regions, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, has a bigger additional segment and also lacks a smaller segment in the C-terminal region, as compared to isoform 1.
    Source sequence(s)
    AK127255, BC014084
    Consensus CDS
    CCDS54254.1
    UniProtKB/Swiss-Prot
    O14559
    Related
    ENSP00000368227.5, ENST00000378944.9
    Conserved Domains (3) summary
    cd11835
    Location:54107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:175369
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:132
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. NM_001366178.1NP_001353107.1  rho GTPase-activating protein 33 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC002398
    Conserved Domains (5) summary
    cd11835
    Location:190243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:311505
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:56168
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl26464
    Location:7091226
    Atrophin-1; Atrophin-1 family
    cl28033
    Location:521869
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  3. NM_052948.4NP_443180.2  rho GTPase-activating protein 33 isoform 1

    See identical proteins and their annotated locations for NP_443180.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK096338, AK127255, AL137579, BC014084, BC128586
    Consensus CDS
    CCDS12477.1
    UniProtKB/Swiss-Prot
    O14559
    UniProtKB/TrEMBL
    A1A5D2
    Related
    ENSP00000320038.4, ENST00000314737.9
    Conserved Domains (3) summary
    cd07299
    Location:56168
    PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein
    cd11835
    Location:190243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:311505
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    35775515..35788822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526420.1XP_011524722.1  rho GTPase-activating protein 33 isoform X7

    Conserved Domains (3) summary
    cd11835
    Location:54107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:176370
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:132
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  2. XM_006722999.2XP_006723062.1  rho GTPase-activating protein 33 isoform X4

    Conserved Domains (3) summary
    cd11835
    Location:190243
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:312506
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:56168
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. XM_017026238.1XP_016881727.1  rho GTPase-activating protein 33 isoform X9

  4. XM_011526421.2XP_011524723.1  rho GTPase-activating protein 33 isoform X10

    Conserved Domains (3) summary
    cd11835
    Location:227280
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:349543
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:93205
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  5. XM_011526418.1XP_011524720.1  rho GTPase-activating protein 33 isoform X3

    Conserved Domains (3) summary
    cd11835
    Location:54107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:176370
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:132
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  6. XM_011526417.1XP_011524719.1  rho GTPase-activating protein 33 isoform X2

    Conserved Domains (3) summary
    cd11835
    Location:54107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:176370
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:132
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  7. XM_011526416.1XP_011524718.1  rho GTPase-activating protein 33 isoform X1

    Conserved Domains (3) summary
    cd11835
    Location:54107
    SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
    cd04384
    Location:175369
    RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    cl02563
    Location:132
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  8. XM_006723003.2XP_006723066.1  rho GTPase-activating protein 33 isoform X8

    Conserved Domains (1) summary
    PHA03247
    Location:455757
    PHA03247; large tegument protein UL36; Provisional

RNA

  1. XR_935731.2 RNA Sequence

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