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Aebp1 AE binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 11568, updated on 11-Jun-2024

Summary

Official Symbol
Aebp1provided by MGI
Official Full Name
AE binding protein 1provided by MGI
Primary source
MGI:MGI:1197012
See related
Ensembl:ENSMUSG00000020473 AllianceGenome:MGI:1197012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACLP
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and carboxypeptidase activity. Acts upstream of or within regulation of transcription, DNA-templated. Located in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skeleton. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome classic-like 2. Orthologous to human AEBP1 (AE binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 317.6), ovary adult (RPKM 195.5) and 7 other tissues See more
Orthologs
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Genomic context

See Aebp1 in Genome Data Viewer
Location:
11 A1; 11 3.88 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5806085..5822248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5861866..5872248)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 2 Neighboring gene STARR-positive B cell enhancer ABC_E9815 Neighboring gene polymerase (DNA directed), mu Neighboring gene STARR-seq mESC enhancer starr_28443 Neighboring gene STARR-positive B cell enhancer ABC_E6946 Neighboring gene polymerase (DNA directed), delta 2, regulatory subunit Neighboring gene predicted gene, 53664 Neighboring gene myosin, light polypeptide 7, regulatory

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adipocyte enhancer-binding protein 1
Names
aortic carboxypeptidase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291857.2NP_001278786.1  adipocyte enhancer-binding protein 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI322823, AK159774, AL627069, BY309657
    UniProtKB/Swiss-Prot
    Q640N1
    Conserved Domains (4) summary
    cd03869
    Location:552895
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:899974
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:376532
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:378531
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_009636.3NP_033766.2  adipocyte enhancer-binding protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_033766.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA162039, AI322823, BC082577, BY309657
    Consensus CDS
    CCDS24406.1
    UniProtKB/Swiss-Prot
    O88442, Q3TVV5, Q3TWA7, Q3TX56, Q3TXB2, Q5NCI9, Q61281, Q640N1
    Related
    ENSMUSP00000099987.4, ENSMUST00000102923.10
    Conserved Domains (3) summary
    cd11308
    Location:898973
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:377530
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:555894
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5806085..5822248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156244.1XP_036012137.1  adipocyte enhancer-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O88442, Q3TVV5, Q3TWA7, Q3TX56, Q3TXB2, Q5NCI9, Q61281, Q640N1
    Conserved Domains (3) summary
    cd11308
    Location:898973
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd00057
    Location:377530
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl11393
    Location:555894
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins