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Adss adenylosuccinate synthetase, non muscle [ Mus musculus (house mouse) ]

Gene ID: 11566, updated on 5-Feb-2023

Summary

Official Symbol
Adssprovided by MGI
Official Full Name
adenylosuccinate synthetase, non muscleprovided by MGI
Primary source
MGI:MGI:87948
See related
Ensembl:ENSMUSG00000015961 AllianceGenome:MGI:87948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AS; Adss2
Summary
Enables adenylosuccinate synthase activity. Involved in 'de novo' AMP biosynthetic process. Acts upstream of or within AMP biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
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Genomic context

See Adss in Genome Data Viewer
Location:
1; 1 H4
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177590742..177624275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177763176..177796695, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310043L19 gene Neighboring gene RIKEN cDNA 1700016C15 gene Neighboring gene predicted gene, 30115 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene cation channel sperm associated auxiliary subunit epsilon 1 Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylosuccinate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylosuccinate synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in 'de novo' AMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in 'de novo' AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within AMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in AMP salvage TAS
Traceable Author Statement
more info
PubMed 
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in IMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in aspartate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adenylosuccinate synthetase isozyme 2
Names
AMPSase 2
IMP--aspartate ligase 2
L-type adenylosuccinate synthetase
adSS 2
adenylosuccinate synthetase 2, non muscle
adenylosuccinate synthetase, acidic isozyme
adenylosuccinate synthetase, liver isozyme
adenylosuccinate synthetase, non-muscle isozyme
NP_031448.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007422.3NP_031448.2  adenylosuccinate synthetase isozyme 2

    See identical proteins and their annotated locations for NP_031448.2

    Status: VALIDATED

    Source sequence(s)
    AK028060
    Consensus CDS
    CCDS15555.1
    UniProtKB/Swiss-Prot
    P46664, Q9CQL9
    UniProtKB/TrEMBL
    B9EIE9
    Related
    ENSMUSP00000016105.9, ENSMUST00000016105.9
    Conserved Domains (1) summary
    pfam00709
    Location:32453
    Adenylsucc_synt; Adenylosuccinate synthetase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    177590742..177624275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001785476.2 RNA Sequence