Adss adenylosuccinate synthetase, non muscle [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adssprovided by MGI
Official Full Name: adenylosuccinate synthetase, non muscleprovided by MGI
Primary source: MGI:MGI:87948
See related: Ensembl:ENSMUSG00000015961 AllianceGenome:MGI:87948
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AS; Adss2
Summary: Enables adenylosuccinate synthase activity. Involved in 'de novo' AMP biosynthetic process. Acts upstream of or within AMP biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 H4

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (177590742..177624275, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (177763176..177796695, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234275

AI314886 (e-PCR)
- UniSTS:178526

Homology

Orthologs from Annotation Pipeline: 468 organisms have orthologs with human gene Adss
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables adenylosuccinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylosuccinate synthase activity	ISO Inferred from Sequence Orthology more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in 'de novo' AMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in 'de novo' AMP biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within AMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in AMP salvage	TAS Traceable Author Statement more info	PubMed
involved_in IMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in IMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine nucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylosuccinate synthetase isozyme 2

Names: AMPSase 2; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase; adSS 2; adenylosuccinate synthetase 2, non muscle; adenylosuccinate synthetase, acidic isozyme; adenylosuccinate synthetase, liver isozyme; adenylosuccinate synthetase, non-muscle isozyme

NP_031448.2

EC 6.3.4.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.