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Adss2 adenylosuccinate synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 11566, updated on 7-Apr-2025

Summary

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Official Symbol
Adss2provided by MGI
Official Full Name
adenylosuccinate synthase 2provided by MGI
Primary source
MGI:MGI:87948
See related
Ensembl:ENSMUSG00000015961 AllianceGenome:MGI:87948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AS; Adss; adSS 2
Summary
Enables adenylosuccinate synthase activity. Involved in 'de novo' AMP biosynthetic process. Acts upstream of or within AMP biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Orthologous to human ADSS2 (adenylosuccinate synthase 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 15.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Adss2 in Genome Data Viewer
Location:
1 H4; 1 82.81 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (177590742..177624064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177763176..177796695, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310043L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E11111 Neighboring gene STARR-seq mESC enhancer starr_03127 Neighboring gene STARR-positive B cell enhancer ABC_E9190 Neighboring gene STARR-seq mESC enhancer starr_03128 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:179630726-179631007 Neighboring gene STARR-positive B cell enhancer ABC_E5863 Neighboring gene STARR-seq mESC enhancer starr_03129 Neighboring gene predicted gene, 30115 Neighboring gene STARR-seq mESC enhancer starr_03132 Neighboring gene STARR-seq mESC enhancer starr_03133 Neighboring gene sperm microtubule inner protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4395 Neighboring gene STARR-positive B cell enhancer ABC_E632 Neighboring gene STARR-seq mESC enhancer starr_03135 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene cation channel sperm associated auxiliary subunit epsilon 1 Neighboring gene STARR-seq mESC enhancer starr_03137 Neighboring gene STARR-positive B cell enhancer ABC_E2589 Neighboring gene cation channel sperm associated auxiliary subunit epsilon 2 Neighboring gene predicted gene, 25312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression. Luo XM, et al. Commun Biol, 2022 Oct 12. PMID 36224248, Free PMC Article
  2. Molecular cloning and expression of a mouse muscle cDNA encoding adenylosuccinate synthetase. Guicherit OM, et al. J Biol Chem, 1991 Nov 25. PMID 1939273
  3. Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction. Swain JL, et al. J Clin Invest, 1984 Oct. PMID 6480832, Free PMC Article
  4. Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells. Molecular cloning of a cDNA encoding the "non-muscle" isozyme. Guicherit OM, et al. J Biol Chem, 1994 Feb 11. PMID 8308018
  5. Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance. Borza T, et al. J Biol Chem, 2003 Feb 28. PMID 12482871

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylosuccinate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylosuccinate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' AMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' AMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 'de novo' AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within AMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP salvage TAS
Traceable Author Statement
more info
 PubMed 
involved_in IMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in IMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in aspartate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aspartate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ammonium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to purine-containing compound IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adenylosuccinate synthetase isozyme 2
Names
AMPSase 2
IMP--aspartate ligase 2
L-type adenylosuccinate synthetase
adenylosuccinate synthetase 2, non muscle
adenylosuccinate synthetase, acidic isozyme
adenylosuccinate synthetase, liver isozyme
adenylosuccinate synthetase, non muscle
adenylosuccinate synthetase, non-muscle isozyme
NP_001406878.1
NP_001406880.1
NP_031448.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419949.1 → NP_001406878.1  adenylosuccinate synthetase isozyme 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157787

  2. NM_001419951.1 → NP_001406880.1  adenylosuccinate synthetase isozyme 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157787

  3. NM_007422.4 → NP_031448.2  adenylosuccinate synthetase isozyme 2 isoform 1

    See identical proteins and their annotated locations for NP_031448.2

    Status: VALIDATED

    Source sequence(s)
    AC157787
    Consensus CDS
    CCDS15555.1
    UniProtKB/Swiss-Prot
    P46664, Q9CQL9
    UniProtKB/TrEMBL
    B9EIE9
    Related
    ENSMUSP00000016105.9, ENSMUST00000016105.9
    Conserved Domains (1) summary
    pfam00709
    Location:32 → 453
    Adenylsucc_synt; Adenylosuccinate synthetase

RNA

  1. NR_185123.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157787

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    177590742..177624064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46664.2 GenPept UniProtKB/Swiss-Prot:P46664

Gene LinkOut

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