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SLC5A11 solute carrier family 5 member 11 [ Homo sapiens (human) ]

Gene ID: 115584, updated on 2-Oct-2018

Summary

Official Symbol
SLC5A11provided by HGNC
Official Full Name
solute carrier family 5 member 11provided by HGNC
Primary source
HGNC:HGNC:23091
See related
Ensembl:ENSG00000158865 MIM:610238; Vega:OTTHUMG00000097003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KST1; RKST1; SGLT6; SMIT2
Summary
Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].[supplied by OMIM, Mar 2008]
Expression
Biased expression in small intestine (RPKM 3.6), brain (RPKM 1.7) and 2 other tissues See more
Orthologs

Genomic context

See SLC5A11 in Genome Data Viewer
Location:
16p12.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (24845863..24911628)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24857184..24922949)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing 6A Neighboring gene long intergenic non-protein coding RNA 1567 Neighboring gene uncharacterized LOC107984825 Neighboring gene uncharacterized LOC107984826 Neighboring gene Rho GTPase activating protein 17 Neighboring gene thyroid hormone receptor interactor 11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Lupus nephritis susceptibility Loci in women with systemic lupus erythematosus.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
polyol transmembrane transporter activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate transport IEA
Inferred from Electronic Annotation
more info
 
myo-inositol transport TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/myo-inositol cotransporter 2
Names
Na(+)/myo-inositol cotransporter 2
homolog of rabbit KST1
putative sodium-coupled cotransporter RKST1
sodium-dependent glucose cotransporter
sodium/glucose cotransporter KST1
sodium/myo-inositol transporter 2
solute carrier family 5 (sodium/glucose cotransporter), member 11
solute carrier family 5 (sodium/inositol cotransporter), member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258411.2NP_001245340.1  sodium/myo-inositol cotransporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001245340.1

    Status: VALIDATED

    Source sequence(s)
    AA772233, AK303691, AY044906, DC332171, KC877600
    Consensus CDS
    CCDS58437.1
    UniProtKB/Swiss-Prot
    Q8WWX8
    UniProtKB/TrEMBL
    B7Z8N3
    Related
    ENSP00000416782.2, ENST00000424767.6
    Conserved Domains (1) summary
    cl00456
    Location:28640
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. NM_001258412.2NP_001245341.1  sodium/myo-inositol cotransporter 2 isoform 3

    See identical proteins and their annotated locations for NP_001245341.1

    Status: VALIDATED

    Source sequence(s)
    AA772233, AK295427, AY044906, DC332171, KC877600
    Consensus CDS
    CCDS58438.1
    UniProtKB/Swiss-Prot
    Q8WWX8
    Related
    ENSP00000441384.1, ENST00000545376.5
    Conserved Domains (1) summary
    cl00456
    Location:28605
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  3. NM_001258413.2NP_001245342.1  sodium/myo-inositol cotransporter 2 isoform 4

    See identical proteins and their annotated locations for NP_001245342.1

    Status: VALIDATED

    Source sequence(s)
    AA772233, AY044906, BC057780, DC332171, KC877600
    Consensus CDS
    CCDS58439.1
    UniProtKB/Swiss-Prot
    Q8WWX8
    Related
    ENSP00000457179.1, OTTHUMP00000256135, ENST00000565769.5, OTTHUMT00000435851
    Conserved Domains (1) summary
    cl00456
    Location:1611
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. NM_001258414.1NP_001245343.1  sodium/myo-inositol cotransporter 2 isoform 5

    See identical proteins and their annotated locations for NP_001245343.1

    Status: VALIDATED

    Source sequence(s)
    AA772233, BC049385, DC332171
    Consensus CDS
    CCDS58440.1
    UniProtKB/Swiss-Prot
    Q8WWX8
    Related
    ENSP00000389606.2, ENST00000449109.6
    Conserved Domains (1) summary
    cl00456
    Location:1519
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. NM_001352235.1NP_001339164.1  sodium/myo-inositol cotransporter 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Conserved Domains (1) summary
    cl00456
    Location:29662
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. NM_001352236.1NP_001339165.1  sodium/myo-inositol cotransporter 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS58439.1
    Conserved Domains (1) summary
    cl00456
    Location:1611
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  7. NM_001352237.1NP_001339166.1  sodium/myo-inositol cotransporter 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Conserved Domains (1) summary
    cl00456
    Location:1576
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  8. NM_001352238.1NP_001339167.1  sodium/myo-inositol cotransporter 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS58437.1
    Related
    ENSP00000454401.1, ENST00000567758.5
    Conserved Domains (1) summary
    cl00456
    Location:28640
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  9. NM_001352242.1NP_001339171.1  sodium/myo-inositol cotransporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS10625.1
    Conserved Domains (1) summary
    cd11490
    Location:28675
    SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain
  10. NM_001352245.1NP_001339174.1  sodium/myo-inositol cotransporter 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731
    Conserved Domains (1) summary
    cl00456
    Location:28583
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  11. NM_001352246.1NP_001339175.1  sodium/myo-inositol cotransporter 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731
    Conserved Domains (1) summary
    cl00456
    Location:28583
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  12. NM_001352247.1NP_001339176.1  sodium/myo-inositol cotransporter 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731
    Conserved Domains (1) summary
    cl00456
    Location:28548
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  13. NM_001352248.1NP_001339177.1  sodium/myo-inositol cotransporter 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS10625.1
    Conserved Domains (1) summary
    cd11490
    Location:28675
    SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain
  14. NM_001352249.1NP_001339178.1  sodium/myo-inositol cotransporter 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS58439.1
    Conserved Domains (1) summary
    cl00456
    Location:1611
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  15. NM_001352250.1NP_001339179.1  sodium/myo-inositol cotransporter 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Conserved Domains (1) summary
    cl00456
    Location:28648
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  16. NM_001352259.1NP_001339188.1  sodium/myo-inositol cotransporter 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Consensus CDS
    CCDS58439.1
    Conserved Domains (1) summary
    cl00456
    Location:1611
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  17. NM_052944.4NP_443176.2  sodium/myo-inositol cotransporter 2 isoform 1

    See identical proteins and their annotated locations for NP_443176.2

    Status: VALIDATED

    Source sequence(s)
    AA772233, AY044906, KC877600
    Consensus CDS
    CCDS10625.1
    UniProtKB/Swiss-Prot
    Q8WWX8
    Related
    ENSP00000289932.3, OTTHUMP00000122494, ENST00000347898.7, OTTHUMT00000214091
    Conserved Domains (1) summary
    cd11490
    Location:28675
    SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain

RNA

  1. NR_147933.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
  2. NR_147934.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
    Related
    ENST00000488922.6
  3. NR_147935.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
  4. NR_147936.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
  5. NR_147938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
  6. NR_147939.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600
  7. NR_147940.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA772233, AC008731, KC877600

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    24845863..24911628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022903.1XP_016878392.1  sodium/myo-inositol cotransporter 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8WWX8
    Conserved Domains (1) summary
    cd11490
    Location:28675
    SLC5sbd_SGLT6; Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain
  2. XM_011545725.2XP_011544027.2  sodium/myo-inositol cotransporter 2 isoform X2

  3. XM_024450145.1XP_024305913.1  sodium/myo-inositol cotransporter 2 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:1514
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  4. XM_024450146.1XP_024305914.1  sodium/myo-inositol cotransporter 2 isoform X4

    Conserved Domains (1) summary
    cl00456
    Location:1422
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  5. XM_005255082.4XP_005255139.1  sodium/myo-inositol cotransporter 2 isoform X3

    See identical proteins and their annotated locations for XP_005255139.1

    Conserved Domains (1) summary
    cl00456
    Location:1514
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  6. XM_011545728.1XP_011544030.1  sodium/myo-inositol cotransporter 2 isoform X5

    Conserved Domains (1) summary
    cl00456
    Location:1365
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
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