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ARHGEF25 Rho guanine nucleotide exchange factor 25 [ Homo sapiens (human) ]

Gene ID: 115557, updated on 1-Jun-2020

Summary

Official Symbol
ARHGEF25provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 25provided by HGNC
Primary source
HGNC:HGNC:30275
See related
Ensembl:ENSG00000240771 MIM:610215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GEFT; p63RhoGEF
Summary
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in endometrium (RPKM 29.1), prostate (RPKM 19.9) and 22 other tissues See more
Orthologs

Genomic context

See ARHGEF25 in Genome Data Viewer
Location:
12q13.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (57610116..57617245)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58003963..58011028)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Neighboring gene deltex E3 ubiquitin ligase 3 Neighboring gene uncharacterized LOC101927583 Neighboring gene solute carrier family 26 member 10 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
myofibril ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcomere IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 25
Names
RAC/CDC42 exchange factor
Rho guanine nucleotide exchange factor (GEF) 25
RhoA/RAC/CDC42 exchange factor
guanine nucleotide exchange factor GEFT
rac/Cdc42/Rho exchange factor GEFT
rhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053182.1 RefSeqGene

    Range
    5001..12066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001111270.3NP_001104740.2  rho guanine nucleotide exchange factor 25 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and in the presence and absence of exons in the 5' coding region, compared to variant 1. The resulting isoform (3) contains a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC025165
    Consensus CDS
    CCDS44931.1
    Related
    ENSP00000335560.7, ENST00000333972.11
  2. NM_001347933.2NP_001334862.2  rho guanine nucleotide exchange factor 25 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC025165
  3. NM_182947.4NP_891992.3  rho guanine nucleotide exchange factor 25 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript (1) and encodes isoform 1.
    Source sequence(s)
    AC025165
    Consensus CDS
    CCDS8947.1
    Related
    ENSP00000286494.4, ENST00000286494.9
    Conserved Domains (2) summary
    cd13241
    Location:339481
    PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
    pfam00621
    Location:164334
    RhoGEF; RhoGEF domain

RNA

  1. NR_046223.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025165
    Related
    ENST00000616622.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    57610116..57617245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133483.2: Suppressed sequence

    Description
    NM_133483.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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