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Adrb2 adrenergic receptor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 11555, updated on 19-Jun-2018
Official Symbol
Adrb2provided by MGI
Official Full Name
adrenergic receptor, beta 2provided by MGI
Primary source
MGI:MGI:87938
See related
Ensembl:ENSMUSG00000045730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Badm; Gpcr7; Adrb-2
Summary
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Orthologs
See Adrb2 in Genome Data Viewer
Location:
18 E1; 18 35.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (62177713..62179981, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (62337470..62339613, complement)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41750 Neighboring gene predicted gene, 36003 Neighboring gene predicted gene 9949 Neighboring gene predicted gene, 46634 Neighboring gene predicted gene, 36124

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
B2 bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase binding IDA
Inferred from Direct Assay
more info
PubMed 
adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
beta2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
beta2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
dopamine binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epinephrine binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
receptor-receptor interaction ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
brown fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
desensitization of G-protein coupled receptor protein signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
diaphragm contraction ISO
Inferred from Sequence Orthology
more info
 
diet induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
heat generation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mini excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of the force of heart contraction by epinephrine ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cold IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
beta-2 adrenergic receptor
Names
beta 2-AR
beta-2 adrenoceptor
beta-2 adrenoreceptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007420.3NP_031446.2  beta-2 adrenergic receptor

    See identical proteins and their annotated locations for NP_031446.2

    Status: REVIEWED

    Source sequence(s)
    AC124430, BB844430, BC032883
    Consensus CDS
    CCDS29289.1
    UniProtKB/Swiss-Prot
    P18762
    Related
    ENSMUSP00000062256.3, ENSMUST00000053640.3
    Conserved Domains (2) summary
    pfam00001
    Location:50326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48340
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    62177713..62179981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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