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Adrb2 adrenergic receptor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 11555, updated on 28-May-2024

Summary

Official Symbol
Adrb2provided by MGI
Official Full Name
adrenergic receptor, beta 2provided by MGI
Primary source
MGI:MGI:87938
See related
Ensembl:ENSMUSG00000045730 AllianceGenome:MGI:87938
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Badm; Gpcr7; Adrb-2
Summary
This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Orthologs
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Genomic context

See Adrb2 in Genome Data Viewer
Location:
18 E1; 18 35.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62310784..62313052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62177713..62179981, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41750 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62334464-62334573 Neighboring gene STARR-seq mESC enhancer starr_44769 Neighboring gene STARR-seq mESC enhancer starr_44770 Neighboring gene predicted gene, 36003 Neighboring gene predicted gene 9949 Neighboring gene predicted gene, 36124 Neighboring gene STARR-seq mESC enhancer starr_44772 Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene predicted gene, 36316

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables B2 bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables beta2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables norepinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables norepinephrine binding ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor-receptor interaction ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel diameter maintenance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brown fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
involved_in diaphragm contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within diet induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heat generation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of lipophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mini excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of the force of heart contraction by epinephrine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of sodium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to catecholamine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cold IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle EXP
Inferred from Experiment
more info
PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beta-2 adrenergic receptor
Names
beta 2-AR
beta-2 adrenoceptor
beta-2 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007420.3NP_031446.2  beta-2 adrenergic receptor

    See identical proteins and their annotated locations for NP_031446.2

    Status: REVIEWED

    Source sequence(s)
    AC124430, BB844430, BC032883
    Consensus CDS
    CCDS29289.1
    UniProtKB/Swiss-Prot
    P18762, Q8BH38
    Related
    ENSMUSP00000062256.4, ENSMUST00000053640.5
    Conserved Domains (2) summary
    pfam00001
    Location:50326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48340
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62310784..62313052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)