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Adrb1 adrenergic receptor, beta 1 [ Mus musculus (house mouse) ]

Gene ID: 11554, updated on 8-Feb-2024

Summary

Official Symbol
Adrb1provided by MGI
Official Full Name
adrenergic receptor, beta 1provided by MGI
Primary source
MGI:MGI:87937
See related
Ensembl:ENSMUSG00000035283 AllianceGenome:MGI:87937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adrb-1; beta-AR
Summary
Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in positive regulation of cold-induced thermogenesis and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Located in membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; exocrine gland; hemolymphoid system gland; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Adrb1 in Genome Data Viewer
Location:
19 D2; 19 51.96 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56710549..56713582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56722117..56725150)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:56761537-56761720 Neighboring gene predicted gene, 32575 Neighboring gene predicted gene, 32718 Neighboring gene rp1 MIF pseudogene Neighboring gene coiled-coil domain containing 186 Neighboring gene STARR-positive B cell enhancer ABC_E5712

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables alpha-2A adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables amine binding ISO
Inferred from Sequence Orthology
more info
 
enables beta1-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta1-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables beta1-adrenergic receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables beta1-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brown fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within diet induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heat generation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate by epinephrine-norepinephrine IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of the force of heart contraction by norepinephrine ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cold IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in neuronal dense core vesicle EXP
Inferred from Experiment
more info
PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
beta-1 adrenergic receptor
Names
beta 1-AR
beta-1 adrenoceptor
beta-1 adrenoreceptor
cardiac beta adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007419.3NP_031445.2  beta-1 adrenergic receptor

    See identical proteins and their annotated locations for NP_031445.2

    Status: VALIDATED

    Source sequence(s)
    AC158549
    Consensus CDS
    CCDS29919.1
    UniProtKB/Swiss-Prot
    B2RVY4, P34971
    UniProtKB/TrEMBL
    Q9CRR2
    Related
    ENSMUSP00000040847.5, ENSMUST00000038949.6
    Conserved Domains (1) summary
    cd15958
    Location:59376
    7tmA_Beta1_AR; beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56710549..56713582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)