Format

Send to:

Choose Destination

TBCB tubulin folding cofactor B [ Homo sapiens (human) ]

Gene ID: 1155, updated on 11-Nov-2018

Summary

Official Symbol
TBCBprovided by HGNC
Official Full Name
tubulin folding cofactor Bprovided by HGNC
Primary source
HGNC:HGNC:1989
See related
Ensembl:ENSG00000105254 MIM:601303; Vega:OTTHUMG00000048143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG22; CKAP1; CKAPI
Expression
Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 13.9) and 25 other tissues See more
Orthologs

Genomic context

See TBCB in Genome Data Viewer
Location:
19q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (36114949..36125948)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36605888..36616849)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene WD repeat domain 62 Neighboring gene ovo like zinc finger 3 Neighboring gene RNA polymerase II subunit I Neighboring gene uncharacterized LOC105372385 Neighboring gene calpain small subunit 1 Neighboring gene cytochrome c oxidase subunit 7A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag CKAP1 protein interacts weakly with HIV-1 CA cores in primary human macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Post-chaperonin tubulin folding pathway, organism-specific biosystem (from REACTOME)
    Post-chaperonin tubulin folding pathway, organism-specific biosystemAlpha and beta tubulin folding intermediates are formed through ATP-dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of i...
  • Protein folding, organism-specific biosystem (from REACTOME)
    Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tubulin-folding cofactor B
Names
cytoskeleton associated protein 1
cytoskeleton-associated protein CKAPI
tubulin-specific chaperone B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281.2NP_001272.2  tubulin-folding cofactor B isoform 1

    See identical proteins and their annotated locations for NP_001272.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI126083, AL555345, BC005969, D49738
    Consensus CDS
    CCDS12488.1
    UniProtKB/Swiss-Prot
    Q99426
    Related
    ENSP00000221855.3, OTTHUMP00000081860, ENST00000221855.7, OTTHUMT00000156291
    Conserved Domains (2) summary
    cd01789
    Location:1093
    Alp11_N; Ubiquitin-like domain of Alp11 tubulin-folding cofactor B
    pfam01302
    Location:161226
    CAP_GLY; CAP-Gly domain
  2. NM_001300971.2NP_001287900.1  tubulin-folding cofactor B isoform 2

    See identical proteins and their annotated locations for NP_001287900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AD001527
    Consensus CDS
    CCDS74344.1
    UniProtKB/Swiss-Prot
    Q99426
    Related
    ENSP00000467487.1, OTTHUMP00000267382, ENST00000585746.1
    Conserved Domains (2) summary
    pfam01302
    Location:110175
    CAP_GLY; CAP-Gly domain
    cl00155
    Location:142
    UBQ; Ubiquitin-like proteins

RNA

  1. NR_155756.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AD001527

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    36114949..36125948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001753601.1 RNA Sequence

Support Center