Adra1a adrenergic receptor, alpha 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adra1aprovided by MGI
Official Full Name: adrenergic receptor, alpha 1aprovided by MGI
Primary source: MGI:MGI:104773
See related: Ensembl:ENSMUSG00000045875 AllianceGenome:MGI:104773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adra1c
Summary: This gene encodes one of several multipass transmembrane proteins that function as G protein-coupled receptors. The encoded protein binds to epinephrine and norepinephrine to mediate signaling in cells of the cardiac, nervous, and other organ systems. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression: Biased expression in frontal lobe adult (RPKM 2.7), lung adult (RPKM 1.9) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14; 14 D1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (66872700..67008689)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (66635251..66771240)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adaptation to exercise-induced stress is not dependent on cardiomyocyte alpha1A-adrenergic receptors.
Title: Adaptation to exercise-induced stress is not dependent on cardiomyocyte α(1A)-adrenergic receptors.
alpha1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.
Title: α(1A)-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice.
alpha1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes.
Title: α(1)-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes.
GPR55 regulates the responsiveness to, but does not dimerise with, alpha1A-adrenoceptors.
Title: GPR55 regulates the responsiveness to, but does not dimerise with, α(1A)-adrenoceptors.
results support an arousal circuit whereby noradrenergic transmission at astrocytic alpha1ARs activates wake-promoting ventral Periaquaductal Gray (Dopamine) neurons via glutamate transmission.
Title: Noradrenergic Transmission at Alpha1-Adrenergic Receptors in the Ventral Periaqueductal Gray Modulates Arousal.
results suggest that the APJ-enhanced response requires alpha1A-AR to contract vessels coordinately
Title: Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction.
Thinner media and lower alpha1-adrenoceptor expression weaken contractions of breast cancer feed arteries in response to sympathetic activity. We propose that abnormalities in breast cancer arteries can be exploited to modify tumor perfusion and thereby either starve cancer cells or facilitate drug and oxygen delivery during chemotherapy or radiotherapy.
Title: Murine breast cancer feed arteries are thin-walled with reduced α(1A)-adrenoceptor expression and attenuated sympathetic vasocontraction.
In the mouse bleomycin model of right ventricular failure, the alpha1A-adrenergic receptor subtype agonist A61603 prevents right ventricular failure.
Title: α(1A)-Subtype adrenergic agonist therapy for the failing right ventricle.
Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration
Title: Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.
Male mouse and marmoset proximal urethral smooth muscle shows strong alpha1A- adrenoceptor-induced contractions and abundant alpha1A-adrenoceptor expression, whereas alpha1A-adrenoceptor-mediated mechanisms are much less important in females.
Title: How important is the α(1)-adrenoceptor in primate and rodent proximal urethra? Sex differences in the contribution of α(1)-adrenoceptor to urethral contractility.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5) 1 citation

General gene information

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Markers

PMC150908P4 (e-PCR)
- UniSTS:271119

PMC123165P1 (e-PCR)
- UniSTS:270443

Adra1a (e-PCR), detects polymorphism
- UniSTS:502758

Homology

Homologs of the Adra1a gene: The Adra1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 337 organisms have orthologs with human gene Adra1a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables alpha1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha1-adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alpha1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in activation of phospholipase C activity	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within adult heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in aging	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell growth involved in cardiac muscle cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-glial cell signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info
involved_in pilomotor reflex	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dopaminergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-1A adrenergic receptor

Names: alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271759.1 → NP_001258688.1 alpha-1A adrenergic receptor isoform 2

See identical proteins and their annotated locations for NP_001258688.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC129570, AK033490, AK085653

Consensus CDS

CCDS70600.1

UniProtKB/TrEMBL

Q8BUE5, Q8BZV1

Related

ENSMUSP00000124322.2, ENSMUST00000159365.8

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001271760.1 → NP_001258689.1 alpha-1A adrenergic receptor isoform 1

See identical proteins and their annotated locations for NP_001258689.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK033490, AK079597, AK085653

Consensus CDS

CCDS27223.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

UniProtKB/TrEMBL

Q8BUE5, Q8BZV1

Related

ENSMUSP00000125354.2, ENSMUST00000161339.2

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001271761.1 → NP_001258690.1 alpha-1A adrenergic receptor isoform 3

See identical proteins and their annotated locations for NP_001258690.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons, and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) has a shorter C-terminus, compared to isoform 1.

Source sequence(s)

AK042759, AK085653

Consensus CDS

CCDS88696.1

UniProtKB/TrEMBL

Q8BUE5, Q8BXZ4

Related

ENSMUSP00000153103.2, ENSMUST00000225182.2

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 294

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_013461.4 → NP_038489.2 alpha-1A adrenergic receptor isoform 1

See identical proteins and their annotated locations for NP_038489.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK033490, AK079597, AK085653

Consensus CDS

CCDS27223.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

UniProtKB/TrEMBL

Q8BUE5, Q8BZV1

Related

ENSMUSP00000053703.2, ENSMUST00000054661.8

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

66872700..67008689

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315800.3 → XP_017171289.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Related

ENSMUSP00000124570.2, ENSMUST00000159068.2

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006518444.5 → XP_006518507.1 alpha-1A adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_006518507.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011244926.4 → XP_011243228.1 alpha-1A adrenergic receptor isoform X2

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011244925.4 → XP_011243227.1 alpha-1A adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_011243227.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006518449.5 → XP_006518512.1 alpha-1A adrenergic receptor isoform X4

Conserved Domains (2) summary

cd14964
Location:28 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 337

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036158409.1 → XP_036014302.1 alpha-1A adrenergic receptor isoform X5

Conserved Domains (2) summary

cd14964
Location:28 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 309

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011244923.4 → XP_011243225.1 alpha-1A adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_011243225.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_011244924.4 → XP_011243226.1 alpha-1A adrenergic receptor isoform X1

See identical proteins and their annotated locations for XP_011243226.1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017315802.2 → XP_017171291.1 alpha-1A adrenergic receptor isoform X6

UniProtKB/TrEMBL

Q8BXZ4

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 294

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_036158407.1 → XP_036014300.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017315801.3 → XP_017171290.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/Swiss-Prot

P97718, Q8BV77

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_036158408.1 → XP_036014301.1 alpha-1A adrenergic receptor isoform X3

UniProtKB/TrEMBL

Q8BUE5

Conserved Domains (1) summary

cd15325
Location:27 → 337

7tmA_alpha1A_AR; alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors