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UHRF2 ubiquitin like with PHD and ring finger domains 2 [ Homo sapiens (human) ]

Gene ID: 115426, updated on 3-Nov-2019

Summary

Official Symbol
UHRF2provided by HGNC
Official Full Name
ubiquitin like with PHD and ring finger domains 2provided by HGNC
Primary source
HGNC:HGNC:12557
See related
Ensembl:ENSG00000147854 MIM:615211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIRF; URF2; RNF107; TDRD23
Summary
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Expression
Ubiquitous expression in bone marrow (RPKM 16.7), lymph node (RPKM 12.5) and 25 other tissues See more
Orthologs

Genomic context

See UHRF2 in Genome Data Viewer
Location:
9p24.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (6413148..6507056)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6413151..6507054)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987046 Neighboring gene selenoprotein T pseudogene 1 Neighboring gene TPD52 like 3 Neighboring gene RNA, 7SL, cytoplasmic 25, pseudogene Neighboring gene glycine decarboxylase Neighboring gene Sharpr-MPRA regulatory region 10661

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33463, DKFZp434B0920, DKFZp686G0837

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
maintenance of DNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase UHRF2
Names
Np95-like ring finger protein
RING finger protein 107
RING-type E3 ubiquitin transferase UHRF2
np95/ICBP90-like RING finger protein
nuclear protein 97
nuclear zinc finger protein NP97
ubiquitin-like PHD and RING finger domain-containing protein 2
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
ubiquitin-like, containing PHD and RING finger domains, 2
ubiquitin-like-containing PHD and RING finger domains protein 2
NP_690856.1
XP_011516006.1
XP_011516007.1
XP_016869742.1
XP_016869743.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152896.3NP_690856.1  E3 ubiquitin-protein ligase UHRF2

    See identical proteins and their annotated locations for NP_690856.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript.
    Source sequence(s)
    AB071698, AF274049, BG709183
    Consensus CDS
    CCDS6469.1
    UniProtKB/Swiss-Prot
    Q96PU4
    Related
    ENSP00000276893.5, ENST00000276893.10
    Conserved Domains (6) summary
    cd01797
    Location:178
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00213
    Location:374
    UBQ; Ubiquitin homologues
    cd00162
    Location:732775
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:346392
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:446614
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:125312
    TTD; Tandem tudor domain within UHRF1

RNA

  1. NR_046386.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate internal exon in the coding region, compared to variant 1, which results in a frameshift and early stop codon. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB071698, AF274049, BC028397
    Related
    ENST00000468435.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    6413148..6507056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014253.1XP_016869742.1  E3 ubiquitin-protein ligase UHRF2 isoform X1

  2. XM_017014254.1XP_016869743.1  E3 ubiquitin-protein ligase UHRF2 isoform X3

    Conserved Domains (4) summary
    cd00162
    Location:452495
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:66112
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:166334
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:832
    TTD; Tandem tudor domain within UHRF1
  3. XM_011517704.2XP_011516006.1  E3 ubiquitin-protein ligase UHRF2 isoform X2

    See identical proteins and their annotated locations for XP_011516006.1

    Conserved Domains (4) summary
    cd00162
    Location:509552
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:123169
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:223391
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:189
    TTD; Tandem tudor domain within UHRF1
  4. XM_011517705.2XP_011516007.1  E3 ubiquitin-protein ligase UHRF2 isoform X2

    See identical proteins and their annotated locations for XP_011516007.1

    Conserved Domains (4) summary
    cd00162
    Location:509552
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:123169
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:223391
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:189
    TTD; Tandem tudor domain within UHRF1

RNA

  1. XR_001746179.1 RNA Sequence

  2. XR_001746180.2 RNA Sequence

  3. XR_001746181.1 RNA Sequence

  4. XR_001746182.1 RNA Sequence

  5. XR_001746178.2 RNA Sequence

  6. XR_428418.4 RNA Sequence

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