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Adora2b adenosine A2b receptor [ Mus musculus (house mouse) ]

Gene ID: 11541, updated on 24-Jan-2023

Summary

Official Symbol
Adora2bprovided by MGI
Official Full Name
adenosine A2b receptorprovided by MGI
Primary source
MGI:MGI:99403
See related
Ensembl:ENSMUSG00000018500 AllianceGenome:MGI:99403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2b; A2BR; A2BAR; AA2BR; ARA2B
Summary
Enables G protein-coupled receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is active in synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 18.0), bladder adult (RPKM 15.8) and 20 other tissues See more
Orthologs
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Genomic context

See Adora2b in Genome Data Viewer
Location:
11; 11 B2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62139810..62157278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62248984..62266452)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 Neighboring gene predicted gene, 39988 Neighboring gene predicted gene, 39985 Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene anaphase-promoting complex subunit 15 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC144574, MGC144575

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of chronic inflammatory response to non-antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to angiotensin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenosine receptor A2b
Names
A2b, Rs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007413.4NP_031439.2  adenosine receptor A2b

    See identical proteins and their annotated locations for NP_031439.2

    Status: VALIDATED

    Source sequence(s)
    AL596110
    Consensus CDS
    CCDS24822.1
    UniProtKB/Swiss-Prot
    Q60614, Q8BXI2
    UniProtKB/TrEMBL
    A0A8C6HHT0
    Related
    ENSMUSP00000018644.3, ENSMUST00000018644.3
    Conserved Domains (2) summary
    pfam00001
    Location:24290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:17134
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62139810..62157278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)