U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adora1 adenosine A1 receptor [ Mus musculus (house mouse) ]

Gene ID: 11539, updated on 5-Jan-2023

Summary

Official Symbol
Adora1provided by MGI
Official Full Name
adenosine A1 receptorprovided by MGI
Primary source
MGI:MGI:99401
See related
Ensembl:ENSMUSG00000042429 AllianceGenome:MGI:99401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ri; A1R; A1AR; AA1R; ARA1; A1-AR
Summary
Predicted to enable several functions, including G protein-coupled adenosine receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of long-term synaptic depression; and negative regulation of mucus secretion. Located in dendritic spine. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 63.0), cerebellum adult (RPKM 30.8) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Adora1 in Genome Data Viewer
Location:
1; 1 E4
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134126953..134163195, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134199215..134235457, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46158 Neighboring gene chitinase-like 1 Neighboring gene myosin binding protein H Neighboring gene predicted gene, 32221 Neighboring gene predicted gene, 24517 Neighboring gene myogenin promoter-associated myogenic regulatory antisense lncRNA

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled adenosine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta/gamma-subunit complex binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables heterotrimeric G-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables purine nucleoside binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in inhibition of non-skeletal tissue mineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of long-term synaptic depression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mucus secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian sleep/wake cycle, sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of long-term synaptic depression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of mucus secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neurotrophin production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nucleoside transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptide secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of respiratory gaseous exchange by nervous system process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in relaxation of vascular associated smooth muscle ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to inorganic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to inorganic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to purine-containing compound ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in temperature homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axolemma ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in endomembrane system ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008533.3NP_001008533.1  adenosine receptor A1 isoform a

    See identical proteins and their annotated locations for NP_001008533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC137104, AK045729, BY257408, DV552876
    Consensus CDS
    CCDS15305.1
    UniProtKB/Swiss-Prot
    Q60612, Q9WUF9
    UniProtKB/TrEMBL
    A0A6P5PCN9, A0A8C6HFR0
    Related
    ENSMUSP00000043522.7, ENSMUST00000038191.8
    Conserved Domains (1) summary
    cd15071
    Location:10299
    7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001039510.2NP_001034599.1  adenosine receptor A1 isoform a

    See identical proteins and their annotated locations for NP_001034599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC137104, AK038774, AK134532, DV552876
    Consensus CDS
    CCDS15305.1
    UniProtKB/Swiss-Prot
    Q60612, Q9WUF9
    UniProtKB/TrEMBL
    A0A6P5PCN9, A0A8C6HFR0, Q8CAH1
    Related
    ENSMUSP00000083656.5, ENSMUST00000086465.6
    Conserved Domains (1) summary
    cd15071
    Location:10299
    7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001282945.1NP_001269874.1  adenosine receptor A1 isoform a

    See identical proteins and their annotated locations for NP_001269874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1, 2, and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC137104, AU080986, DV552876
    Consensus CDS
    CCDS15305.1
    UniProtKB/Swiss-Prot
    Q60612, Q9WUF9
    UniProtKB/TrEMBL
    A0A6P5PCN9, A0A8C6HFR0
    Conserved Domains (1) summary
    cd15071
    Location:10299
    7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001291928.1NP_001278857.1  adenosine receptor A1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 2. The encoded protein (isoform b) has a distinct N-terminus and is shorter, compared to isoform a.
    Source sequence(s)
    AC137104, AK045729, BC079624, BY737264, DV552876
    UniProtKB/Swiss-Prot
    Q60612
    UniProtKB/TrEMBL
    Q6AXD8
    Conserved Domains (1) summary
    pfam00001
    Location:23198
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. NM_001291930.1NP_001278859.1  adenosine receptor A1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded protein (isoform c) is shorter, compared to isoform a.
    Source sequence(s)
    AK134532, AK134709, AK141531, BC058421, DV552876
    UniProtKB/TrEMBL
    Q3URG8, Q3UYG0
    Conserved Domains (1) summary
    pfam00001
    Location:58146
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134126953..134163195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529079.4XP_006529142.1  adenosine receptor A1 isoform X1

    See identical proteins and their annotated locations for XP_006529142.1

    UniProtKB/Swiss-Prot
    Q60612, Q9WUF9
    UniProtKB/TrEMBL
    A0A6P5PCN9, A0A8C6HFR0
    Conserved Domains (1) summary
    cd15071
    Location:10299
    7tmA_Adenosine_R_A1; adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009629.3: Suppressed sequence

    Description
    NM_009629.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.