Format

Send to:

Choose Destination

Cfd complement factor D (adipsin) [ Mus musculus (house mouse) ]

Gene ID: 11537, updated on 17-Nov-2020

Summary

Official Symbol
Cfdprovided by MGI
Official Full Name
complement factor D (adipsin)provided by MGI
Primary source
MGI:MGI:87931
See related
Ensembl:ENSMUSG00000061780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; DF; Adn
Summary
This gene encodes a serine protease that plays an important role in the alternative pathway of complement activation for pathogen recognition and elimination. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme that in turn cleaves factor B in the complement pathway. This gene is expressed in adipocytes and the mature enzyme is secreted into the bloodstream. Mice lacking the encoded product cannot initiate alternative pathway of complement activation. [provided by RefSeq, Jul 2016]
Expression
Biased expression in mammary gland adult (RPKM 11182.1), subcutaneous fat pad adult (RPKM 7523.9) and 4 other tissues See more
Orthologs

Genomic context

See Cfd in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79726687..79728489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79890853..79892655)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79353598..79355401)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene elastase, neutrophil expressed Neighboring gene 40S ribosomal protein S21 pseudogene Neighboring gene mediator complex subunit 16 Neighboring gene predicted gene, 24019

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
complement activation, alternative pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
retina development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
vascular associated smooth muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement factor D
Names
28 kDa adipocyte protein
C3 convertase activator
D component (adipsin) of complement
properdin factor D
NP_001278844.1
NP_001316470.1
NP_038487.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291915.2NP_001278844.1  complement factor D isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001278844.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AA512566, BC145412
    Consensus CDS
    CCDS88051.1
    UniProtKB/Swiss-Prot
    P03953
    UniProtKB/TrEMBL
    B7ZNS9
    Related
    ENSMUSP00000151894.1, ENSMUST00000217837.1
    Conserved Domains (2) summary
    smart00020
    Location:24248
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25251
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001329541.1NP_001316470.1  complement factor D isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of 5' coding region and initiates translation an alternate start site, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA512566, BC138778
    UniProtKB/TrEMBL
    Q3UP47
    Conserved Domains (2) summary
    smart00020
    Location:4180
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:4183
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_013459.4NP_038487.1  complement factor D isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_038487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA512566, BC138778
    Consensus CDS
    CCDS23995.1
    UniProtKB/Swiss-Prot
    P03953
    UniProtKB/TrEMBL
    Q3UP47
    Related
    ENSMUSP00000056836.7, ENSMUST00000061653.8
    Conserved Domains (2) summary
    smart00020
    Location:25249
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:26252
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79726687..79728489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center