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GBP5 guanylate binding protein 5 [ Homo sapiens (human) ]

Gene ID: 115362, updated on 19-Sep-2021

Summary

Official Symbol
GBP5provided by HGNC
Official Full Name
guanylate binding protein 5provided by HGNC
Primary source
HGNC:HGNC:19895
See related
Ensembl:ENSG00000154451 MIM:611467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBP-5
Summary
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Expression
Biased expression in appendix (RPKM 33.2), lymph node (RPKM 19.8) and 11 other tissues See more
Orthologs
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Genomic context

See GBP5 in Genome Data Viewer
Location:
1p22.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89256189..89272860, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89724633..89738543, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985076 Neighboring gene uncharacterized LOC105378843 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene intraflagellar transport associated protein pseudogene Neighboring gene guanylate binding protein family member 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 assembly is restricted by GBP5 in HEK293T cells, SupT1 cells, primary PBMC, and macrophages as shown through mutational analysis (C583), overexpression, and siRNA knockdown of GBP5 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed
Tat tat HIV-1 Tat upregulates the expression of guanylate binding protein 5 (GBP5) in human primary T cells PubMed
Vif vif HIV-1 Vif downregulates the expression of guanylate binding protein 5 (GBP5) in Vif-expression T cells PubMed
Vpr vpr Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpr may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed
Vpu vpu Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of GBP5 against production of infectious wild-type HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GBP4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanylate-binding protein 5
Names
GBP-TA antigen
GTP-binding protein 5
guanine nucleotide-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052816.1 RefSeqGene

    Range
    5002..18912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134486.4NP_001127958.1  guanylate-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001127958.1

    Status: REVIEWED

    Source sequence(s)
    AC099063
    Consensus CDS
    CCDS722.1
    UniProtKB/Swiss-Prot
    Q96PP8
    Conserved Domains (2) summary
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282574
    GBP_C; Guanylate-binding protein, C-terminal domain
  2. NM_001391920.1NP_001378849.1  guanylate-binding protein 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC099063
    Related
    ENSP00000403010.1, ENST00000443807.1
    Conserved Domains (2) summary
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282454
    GBP_C; Guanylate-binding protein, C-terminal domain
  3. NM_052942.5NP_443174.1  guanylate-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_443174.1

    Status: REVIEWED

    Source sequence(s)
    AC099063
    Consensus CDS
    CCDS722.1
    UniProtKB/Swiss-Prot
    Q96PP8
    Related
    ENSP00000359488.3, ENST00000370459.7
    Conserved Domains (2) summary
    pfam02263
    Location:18280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282574
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89256189..89272860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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