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GBP4 guanylate binding protein 4 [ Homo sapiens (human) ]

Gene ID: 115361, updated on 21-Dec-2019

Summary

Official Symbol
GBP4provided by HGNC
Official Full Name
guanylate binding protein 4provided by HGNC
Primary source
HGNC:HGNC:20480
See related
Ensembl:ENSG00000162654 MIM:612466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mpa2
Summary
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
Expression
Broad expression in lung (RPKM 16.3), lymph node (RPKM 13.8) and 23 other tissues See more
Orthologs

Genomic context

See GBP4 in Genome Data Viewer
Location:
1p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (89181144..89198942, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89646831..89664633, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268267 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene guanylate binding protein 7 Neighboring gene uncharacterized LOC107985076 Neighboring gene uncharacterized LOC105378843

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of guanylate binding protein 4 (GBP4) expression as compared to untreated control PubMed
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 4 (GBP4) in primary human brain microvascular endothelial cells PubMed
Vif vif HIV-1 Vif upregulates the expression of guanylate binding protein 4 (GBP4) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Potential readthrough

Included gene: GBP5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
symbiont-containing vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
guanylate-binding protein 4
Names
GBP-4
GTP-binding protein 4
guanine nucleotide-binding protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052941.5NP_443173.2  guanylate-binding protein 4

    See identical proteins and their annotated locations for NP_443173.2

    Status: VALIDATED

    Source sequence(s)
    AC104459, AF288814, BC008421, BC070055, CA309701
    Consensus CDS
    CCDS721.1
    UniProtKB/Swiss-Prot
    Q96PP9
    Related
    ENSP00000359490.5, ENST00000355754.7
    Conserved Domains (3) summary
    pfam02841
    Location:298594
    GBP_C; Guanylate-binding protein, C-terminal domain
    pfam02263
    Location:33296
    GBP; Guanylate-binding protein, N-terminal domain
    cd16269
    Location:304594
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    89181144..89198942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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