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LRRC42 leucine rich repeat containing 42 [ Homo sapiens (human) ]

Gene ID: 115353, updated on 13-Mar-2020

Summary

Official Symbol
LRRC42provided by HGNC
Official Full Name
leucine rich repeat containing 42provided by HGNC
Primary source
HGNC:HGNC:28792
See related
Ensembl:ENSG00000116212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ167A19.4
Expression
Ubiquitous expression in thyroid (RPKM 11.3), testis (RPKM 10.8) and 25 other tissues See more
Orthologs

Genomic context

See LRRC42 in Genome Data Viewer
Location:
1p32.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (53946350..53968168)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54411999..54433841)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene iodothyronine deiodinase 1 Neighboring gene heat shock protein family B (small) member 11 Neighboring gene Sharpr-MPRA regulatory region 11594 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 12 Neighboring gene low density lipoprotein receptor class A domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8974

General protein information

Preferred Names
leucine-rich repeat-containing protein 42

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256409.2NP_001243338.1  leucine-rich repeat-containing protein 42

    See identical proteins and their annotated locations for NP_001243338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK095767, CB851494, CX783955
    Consensus CDS
    CCDS585.1
    UniProtKB/Swiss-Prot
    Q9Y546
    Related
    ENSP00000360421.3, ENST00000371370.8
    Conserved Domains (2) summary
    sd00034
    Location:175202
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl26161
    Location:167272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_052940.5NP_443172.1  leucine-rich repeat-containing protein 42

    See identical proteins and their annotated locations for NP_443172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075201, CB851494, CX783955
    Consensus CDS
    CCDS585.1
    UniProtKB/Swiss-Prot
    Q9Y546
    Related
    ENSP00000318185.4, ENST00000319223.8
    Conserved Domains (2) summary
    sd00034
    Location:175202
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl26161
    Location:167272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    53946350..53968168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710328.4XP_006710391.1  leucine-rich repeat-containing protein 42 isoform X1

    See identical proteins and their annotated locations for XP_006710391.1

    UniProtKB/Swiss-Prot
    Q9Y546
    Conserved Domains (2) summary
    sd00034
    Location:175202
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl26161
    Location:167272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_006710327.3XP_006710390.1  leucine-rich repeat-containing protein 42 isoform X1

    See identical proteins and their annotated locations for XP_006710390.1

    UniProtKB/Swiss-Prot
    Q9Y546
    Conserved Domains (2) summary
    sd00034
    Location:175202
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl26161
    Location:167272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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