Format

Send to:

Choose Destination

FCRL3 Fc receptor like 3 [ Homo sapiens (human) ]

Gene ID: 115352, updated on 12-Oct-2019

Summary

Official Symbol
FCRL3provided by HGNC
Official Full Name
Fc receptor like 3provided by HGNC
Primary source
HGNC:HGNC:18506
See related
Ensembl:ENSG00000160856 MIM:606510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Biased expression in lymph node (RPKM 31.5), spleen (RPKM 20.4) and 2 other tissues See more
Orthologs

Genomic context

See FCRL3 in Genome Data Viewer
Location:
1q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (157676481..157700985, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157646271..157670775, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc receptor like 4 Neighboring gene uncharacterized LOC105371457 Neighboring gene SON pseudogene 1 Neighboring gene voltage dependent anion channel 1 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies two new risk loci for Graves' disease.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Fc receptor-like protein 3
Names
Fc receptor homolog 3
IFGP family protein 3
SH2 domain-containing phosphatase anchor protein 2
fcR-like protein 3
hIFGP3
immune receptor translocation-associated protein 3
immunoglobulin superfamily receptor translocation associated protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023241.1 RefSeqGene

    Range
    5089..29377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320333.2NP_001307262.1  Fc receptor-like protein 3 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (3).
    Source sequence(s)
    BC028933, BF514552, HY081176
    Consensus CDS
    CCDS81385.1
    UniProtKB/Swiss-Prot
    Q96P31
    Related
    ENSP00000357169.5, ENST00000368186.9
    Conserved Domains (4) summary
    smart00410
    Location:301376
    IG_like; Immunoglobulin like
    pfam13895
    Location:290376
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:475548
    Ig_3; Immunoglobulin domain
    cl11960
    Location:2397
    Ig; Immunoglobulin domain
  2. NM_052939.4NP_443171.2  Fc receptor-like protein 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443171.2

    Status: REVIEWED

    Source sequence(s)
    AF459027, AL356276, CD690165
    Consensus CDS
    CCDS1167.1
    UniProtKB/Swiss-Prot
    Q96P31
    Related
    ENSP00000357167.3, ENST00000368184.8
    Conserved Domains (4) summary
    smart00410
    Location:301376
    IG_like; Immunoglobulin like
    pfam13895
    Location:290376
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:475548
    Ig_3; Immunoglobulin domain
    cl11960
    Location:2397
    Ig; Immunoglobulin domain

RNA

  1. NR_135214.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in two internal exons, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF416903, BF514552, HY081176
    Related
    ENST00000492769.5
  2. NR_135215.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF416901, BF514552, HY081176
    Related
    ENST00000480682.5
  3. NR_135216.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses alternate splice sites in two internal exons, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF416905, BF514552, HY081176
    Related
    ENST00000494724.5
  4. NR_135217.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an internal exon and uses an alternate splice site in an internal exon, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF416902, BF514552, HY081176
    Related
    ENST00000477837.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    157676481..157700985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711145.1XP_006711208.1  Fc receptor-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006711208.1

    UniProtKB/Swiss-Prot
    Q96P31
    Conserved Domains (4) summary
    smart00410
    Location:301376
    IG_like; Immunoglobulin like
    pfam13895
    Location:290376
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:475548
    Ig_3; Immunoglobulin domain
    cl11960
    Location:2397
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024667.1: Suppressed sequence

    Description
    NM_001024667.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center