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FCRL1 Fc receptor like 1 [ Homo sapiens (human) ]

Gene ID: 115350, updated on 11-Jun-2021

Summary

Official Symbol
FCRL1provided by HGNC
Official Full Name
Fc receptor like 1provided by HGNC
Primary source
HGNC:HGNC:18509
See related
Ensembl:ENSG00000163534 MIM:606508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRH1; IFGP1; IRTA5; CD307a
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues See more
Orthologs
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Genomic context

See FCRL1 in Genome Data Viewer
Location:
1q23.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (157792249..157820134, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157764193..157789910, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene Fc receptor like 2 Neighboring gene CD5 molecule like Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp667O1421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like protein 1
Names
IFGP family protein 1
fc receptor homolog 1
fcR-like protein 1
hIFGP1
immune receptor translocation-associated protein 5
immunoglobulin superfamily Fc receptor, gp42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159397.2NP_001152869.1  Fc receptor-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001152869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK096690, AL356276, AL833674, DA939902
    Consensus CDS
    CCDS53382.1
    UniProtKB/Swiss-Prot
    Q96LA6
    Related
    ENSP00000351039.3, ENST00000358292.7
    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  2. NM_001159398.2NP_001152870.1  Fc receptor-like protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001152870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AF329488, AL356276, AL833674, DA939902
    Consensus CDS
    CCDS53383.1
    UniProtKB/Swiss-Prot
    Q96LA6
    Related
    ENSP00000418130.1, ENST00000491942.1
    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  3. NM_052938.5NP_443170.1  Fc receptor-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL356276, AL833674, AY043464, DA939902
    Consensus CDS
    CCDS1170.1
    UniProtKB/Swiss-Prot
    Q96LA6
    Related
    ENSP00000357158.3, ENST00000368176.8
    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:1990
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    157792249..157820134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244869.3XP_005244926.1  Fc receptor-like protein 1 isoform X12

    Conserved Domains (2) summary
    smart00410
    Location:23105
    IG_like; Immunoglobulin like
    pfam13927
    Location:111184
    Ig_3; Immunoglobulin domain
  2. XM_011509127.2XP_011507429.1  Fc receptor-like protein 1 isoform X3

    Conserved Domains (3) summary
    smart00410
    Location:112194
    IG_like; Immunoglobulin like
    pfam13895
    Location:108194
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:200273
    Ig_3; Immunoglobulin domain
  3. XM_011509135.2XP_011507437.1  Fc receptor-like protein 1 isoform X11

    Conserved Domains (2) summary
    smart00410
    Location:30112
    IG_like; Immunoglobulin like
    pfam13927
    Location:118191
    Ig_3; Immunoglobulin domain
  4. XM_005244867.2XP_005244924.1  Fc receptor-like protein 1 isoform X9

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  5. XM_011509130.1XP_011507432.1  Fc receptor-like protein 1 isoform X7

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  6. XM_005244866.2XP_005244923.1  Fc receptor-like protein 1 isoform X6

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  7. XM_011509129.1XP_011507431.1  Fc receptor-like protein 1 isoform X5

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  8. XM_011509128.1XP_011507430.1  Fc receptor-like protein 1 isoform X4

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  9. XM_011509126.1XP_011507428.1  Fc receptor-like protein 1 isoform X2

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  10. XM_011509125.1XP_011507427.1  Fc receptor-like protein 1 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  11. XM_011509133.2XP_011507435.1  Fc receptor-like protein 1 isoform X10

    See identical proteins and their annotated locations for XP_011507435.1

    Conserved Domains (3) summary
    smart00410
    Location:44126
    IG_like; Immunoglobulin like
    pfam13895
    Location:40126
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:132205
    Ig_3; Immunoglobulin domain
  12. XM_011509134.2XP_011507436.1  Fc receptor-like protein 1 isoform X10

    See identical proteins and their annotated locations for XP_011507436.1

    Conserved Domains (3) summary
    smart00410
    Location:44126
    IG_like; Immunoglobulin like
    pfam13895
    Location:40126
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:132205
    Ig_3; Immunoglobulin domain
  13. XM_017000227.1XP_016855716.1  Fc receptor-like protein 1 isoform X10

    Conserved Domains (3) summary
    smart00410
    Location:44126
    IG_like; Immunoglobulin like
    pfam13895
    Location:40126
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:132205
    Ig_3; Immunoglobulin domain
  14. XM_011509137.2XP_011507439.1  Fc receptor-like protein 1 isoform X14

    Conserved Domains (2) summary
    smart00410
    Location:579
    IG_like; Immunoglobulin like
    pfam13927
    Location:270
    Ig_3; Immunoglobulin domain
  15. XM_011509131.1XP_011507433.1  Fc receptor-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011507433.1

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  16. XM_011509132.2XP_011507434.1  Fc receptor-like protein 1 isoform X8

    See identical proteins and their annotated locations for XP_011507434.1

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain
  17. XM_011509136.1XP_011507438.1  Fc receptor-like protein 1 isoform X13

    Conserved Domains (3) summary
    smart00410
    Location:119201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207280
    Ig_3; Immunoglobulin domain

RNA

  1. XR_921738.1 RNA Sequence

  2. XR_921740.1 RNA Sequence

  3. XR_921739.1 RNA Sequence

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