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FBXO17 F-box protein 17 [ Homo sapiens (human) ]

Gene ID: 115290, updated on 8-Jul-2021

Summary

Official Symbol
FBXO17provided by HGNC
Official Full Name
F-box protein 17provided by HGNC
Primary source
HGNC:HGNC:18754
See related
Ensembl:ENSG00000269190 MIM:609094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBG4; FBX26; Fbx17; FBXO26
Summary
This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Broad expression in kidney (RPKM 11.1), ovary (RPKM 9.9) and 23 other tissues See more
Orthologs
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Genomic context

See FBXO17 in Genome Data Viewer
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38941401..38975742, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39432041..39466382, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene seryl-tRNA synthetase 2, mitochondrial Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene F-box protein 27 Neighboring gene acid phosphatase 7, tartrate resistant (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: SARS2

Homology

Clone Names

  • MGC9379, FLJ11798, FLJ25205, FLJ58300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
F-box only protein 17
Names
F-box only protein 26
F-box protein FBG4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050566.1 RefSeqGene

    Range
    5072..39413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024907.7NP_079183.4  F-box only protein 17 isoform 2

    See identical proteins and their annotated locations for NP_079183.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the shorter isoform (2).
    Source sequence(s)
    AF386743, AI050825, BM711851, CA429117, CF594009
    Consensus CDS
    CCDS12526.1
    UniProtKB/Swiss-Prot
    Q96EF6
    Related
    ENSP00000292852.3, ENST00000292852.9
    Conserved Domains (2) summary
    pfam04300
    Location:100271
    FBA; F-box associated region
    pfam12937
    Location:1859
    F-box-like
  2. NM_148169.3NP_680474.1  F-box only protein 17 isoform 1

    See identical proteins and their annotated locations for NP_680474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 2. It encodes isoform 1, which has a longer N-terminus, compared to isoform 2.
    Source sequence(s)
    AF386743, AI050825, AK057934, BM711851, CA429117
    UniProtKB/Swiss-Prot
    Q96EF6
    Conserved Domains (2) summary
    pfam04300
    Location:110282
    FBA; F-box associated region
    pfam12937
    Location:2768
    F-box-like; F-box-like

RNA

  1. NR_104026.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and uses an alternate splice site in an internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF386743, AI050825, BM711851, BX338290, CA429117, CF594009

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38941401..38975742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_014040929.1 Reference GRCh38.p13 PATCHES

    Range
    351073..385414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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