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RAB42 RAB42, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 115273, updated on 23-Nov-2021

Summary

Official Symbol
RAB42provided by HGNC
Official Full Name
RAB42, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:28702
See related
Ensembl:ENSG00000188060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in lymph node (RPKM 2.8), placenta (RPKM 2.4) and 23 other tissues See more
Orthologs
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Genomic context

See RAB42 in Genome Data Viewer
Location:
1p35.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28592265..28596666)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28918777..28923178)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA, H/ACA box 44 Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene Sharpr-MPRA regulatory region 12118 Neighboring gene TAF12 divergent transcript Neighboring gene RNA, U11 small nuclear

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45806

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-42
Names
RAB42, member RAS homolog family
putative Ras-related protein Rab-42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193532.3NP_001180461.1  ras-related protein Rab-42 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL513497
    Consensus CDS
    CCDS85943.1
    UniProtKB/Swiss-Prot
    Q8N4Z0
    Related
    ENSP00000491546.1, ENST00000465518.3
    Conserved Domains (1) summary
    cl21455
    Location:8196
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001385188.1NP_001372117.1  ras-related protein Rab-42 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL513497
    Conserved Domains (1) summary
    cl38936
    Location:886
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. NM_152304.3NP_689517.1  ras-related protein Rab-42 isoform 2

    See identical proteins and their annotated locations for NP_689517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL513497, BC033175, BX110464
    Consensus CDS
    CCDS325.1
    UniProtKB/Swiss-Prot
    Q8N4Z0
    Related
    ENSP00000362932.3, ENST00000373826.3
    Conserved Domains (1) summary
    cl21455
    Location:583
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    28592265..28596666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000226.1XP_016855715.1  ras-related protein Rab-42 isoform X1

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