Adh1 alcohol dehydrogenase 1 (class I) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adh1provided by MGI
Official Full Name: alcohol dehydrogenase 1 (class I)provided by MGI
Primary source: MGI:MGI:87921
See related: Ensembl:ENSMUSG00000074207 AllianceGenome:MGI:87921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adh-1; ADH-A2; ADH-AA; Adh-1e; Adh-1t; Adh-3e; Adh1-e; Adh1-t; Adh1tl; Adh3-e; Adh-1-t
Summary: Enables alcohol dehydrogenase (NAD+) activity and identical protein binding activity. Acts upstream of or within several processes, including behavioral response to ethanol; ethanol catabolic process; and retinoid metabolic process. Located in mitochondrion. Is expressed in several structures, including endocrine gland; epidermis; genitourinary system; intestine; and sensory organ. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 1139.9), adrenal adult (RPKM 886.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 64.16 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (137983346..137996459)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138277585..138290698)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Title: ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.
Title: Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.
It is responsible for systemic alcohol metabolism.
Title: Metabolic pharmacokinetics of early chronic alcohol consumption mediated by liver alcohol dehydrogenases 1 and 3 in mice.
Overexpression of an ADH1 transgene protected against tunicamycin-induced cardiac dysfunction through attenuation of ER stress, oxidative stress, and PTEN-Akt-mTOR regulated autophagy.
Title: Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
Data indicate a potential change in aldehyde dehydrogenase (ALDH) activity of proliferating beta cells during pregnancy.
Title: ALDH expression characterizes G1-phase proliferating beta cells during pregnancy.
regulation of human class I alcohol dehydrogenases by bile acids
Title: Regulation of human class I alcohol dehydrogenases by bile acids.
This study demonistrated that adh1 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
Title: Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease.
Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase
Title: Retinol/ethanol drug interaction during acute alcohol intoxication in mice involves inhibition of retinol metabolism to retinoic acid by alcohol dehydrogenase.
Results describe the expression patterns of alcohol dehydrogenases I, III, and IV in adult rat, mouse and human tissues using radioactive oligonucleotide in situ hybridization.
Title: Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain.
Cellular expression of Adh1 in the GI tract was studied.
Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adh1 (e-PCR), detects polymorphism
- UniSTS:470547

Adh1 (e-PCR), detects polymorphism
- UniSTS:507970

Adh1 (e-PCR), detects polymorphism
- UniSTS:186486

Adh1 (e-PCR), detects polymorphism
- UniSTS:461945

RH94448 (e-PCR)
- UniSTS:119696

GDB:187387 (e-PCR)
- UniSTS:155548

Adh1 (e-PCR), detects polymorphism
- UniSTS:508358

40.MMHAP17FRF10.seq (e-PCR)
- UniSTS:124358

AI194826 (e-PCR)
- UniSTS:185566

Adh1 (e-PCR), detects polymorphism
- UniSTS:141035

M18480 (e-PCR)
- UniSTS:124925

Homology

Homologs of the Adh1 gene: The Adh1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 37 organisms have orthologs with human gene Adh1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables NAD-retinol dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables NAD-retinol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	TAS Traceable Author Statement more info	PubMed
enables alcohol dehydrogenase activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables alcohol dehydrogenase activity, zinc-dependent	ISO Inferred from Sequence Orthology more info
enables ethanol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetaldehyde biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ethanol catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ethanol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanol oxidation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ethanol oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to steroid hormone	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to testosterone	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinoid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retinol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alcohol dehydrogenase 1

Names: alcohol dehydrogenase 1 temporal, liver; alcohol dehydrogenase 1, complex; alcohol dehydrogenase 1, electrophoretic; alcohol dehydrogenase 3, electrophoretic; alcohol dehydrogenase A subunit; class I alcohol dehydrogenase

NP_031435.1

EC 1.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007409.3 → NP_031435.1 alcohol dehydrogenase 1

See identical proteins and their annotated locations for NP_031435.1

Status: VALIDATED

Source sequence(s)

AC079682, AI256543, AI326887, CD355981, DV044803

Consensus CDS

CCDS17867.1

UniProtKB/Swiss-Prot

P00329

UniProtKB/TrEMBL

Q3UKA4

Related

ENSMUSP00000004232.10, ENSMUST00000004232.10

Conserved Domains (2) summary

cd08299
Location:3 → 375

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

COG1062
Location:8 → 375

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]