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OMA1 OMA1 zinc metallopeptidase [ Homo sapiens (human) ]

Gene ID: 115209, updated on 13-Mar-2020

Summary

Official Symbol
OMA1provided by HGNC
Official Full Name
OMA1 zinc metallopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:29661
See related
Ensembl:ENSG00000162600 MIM:617081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DAB1; MPRP1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik
Expression
Ubiquitous expression in kidney (RPKM 9.7), prostate (RPKM 9.5) and 25 other tissues See more
Orthologs

Genomic context

See OMA1 in Genome Data Viewer
Location:
1p32.2-p32.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (58480719..58546726, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (58881052..59012469, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 1 Neighboring gene VKORC1 pseudogene 2 Neighboring gene uncharacterized LOC107984960 Neighboring gene RNA, 7SL, cytoplasmic 713, pseudogene Neighboring gene tumor associated calcium signal transducer 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DAB1

Homology

Clone Names

  • FLJ33782

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cristae formation IEA
Inferred from Electronic Annotation
more info
 
diet induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein quality control for misfolded or incompletely synthesized proteins IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
metalloendopeptidase OMA1, mitochondrial
Names
OMA1 homolog, zinc metallopeptidase
OMA1 zinc metallopeptidase homolog
metalloprotease-related protein 1
overlapping activity with M-AAA protease
overlapping with the m-AAA protease 1 homolog
zinc metallopeptidase OMA1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145243.5NP_660286.1  metalloendopeptidase OMA1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_660286.1

    Status: VALIDATED

    Source sequence(s)
    AL109845, AL365187
    Consensus CDS
    CCDS608.1
    UniProtKB/Swiss-Prot
    Q96E52
    Related
    ENSP00000360270.3, ENST00000371226.8
    Conserved Domains (1) summary
    cd07331
    Location:263456
    M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    58480719..58546726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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