Format

Send to:

Choose Destination

ZNF554 zinc finger protein 554 [ Homo sapiens (human) ]

Gene ID: 115196, updated on 5-Jan-2022

Summary

Official Symbol
ZNF554provided by HGNC
Official Full Name
zinc finger protein 554provided by HGNC
Primary source
HGNC:HGNC:26629
See related
Ensembl:ENSG00000172006
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in brain (RPKM 1.5), placenta (RPKM 1.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF554 in Genome Data Viewer
Location:
19p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2819868..2836735)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2819866..2836733)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone alpha Neighboring gene thimet oligopeptidase 1 Neighboring gene zinc finger protein 555 Neighboring gene 60S ribosomal protein L35a-like Neighboring gene zinc finger protein 556

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34817

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102651.2NP_001096121.1  zinc finger protein 554

    See identical proteins and their annotated locations for NP_001096121.1

    Status: VALIDATED

    Source sequence(s)
    AC006130, AC006538, AK027860, AK092136, BC000113, BF772510, DC319914
    Consensus CDS
    CCDS42462.1
    UniProtKB/Swiss-Prot
    Q86TJ5
    UniProtKB/TrEMBL
    B3KNM4
    Related
    ENSP00000321132.4, ENST00000317243.10
    Conserved Domains (4) summary
    COG5048
    Location:350532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:324346
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4484
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2819868..2836735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026234.1XP_016881723.1  zinc finger protein 554 isoform X1

  2. XM_011527667.3XP_011525969.1  zinc finger protein 554 isoform X4

    Conserved Domains (2) summary
    smart00349
    Location:4589
    KRAB; krueppel associated box
    pfam01352
    Location:4584
    KRAB; KRAB box
  3. XM_011527664.3XP_011525966.1  zinc finger protein 554 isoform X3

    See identical proteins and their annotated locations for XP_011525966.1

    Conserved Domains (4) summary
    COG5048
    Location:200382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174196
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011527660.2XP_011525962.1  zinc finger protein 554 isoform X2

    See identical proteins and their annotated locations for XP_011525962.1

    Conserved Domains (6) summary
    smart00349
    Location:186
    KRAB; krueppel associated box
    COG5048
    Location:299481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:133
    KRAB; KRAB box
    pfam13465
    Location:427452
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011527662.2XP_011525964.1  zinc finger protein 554 isoform X2

    See identical proteins and their annotated locations for XP_011525964.1

    Conserved Domains (6) summary
    smart00349
    Location:186
    KRAB; krueppel associated box
    COG5048
    Location:299481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:331351
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:273295
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:133
    KRAB; KRAB box
    pfam13465
    Location:427452
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017026235.1XP_016881724.1  zinc finger protein 554 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:200382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174196
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain
  7. XM_006722635.3XP_006722698.1  zinc finger protein 554 isoform X3

    See identical proteins and their annotated locations for XP_006722698.1

    Conserved Domains (4) summary
    COG5048
    Location:200382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174196
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017026236.1XP_016881725.1  zinc finger protein 554 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:200382
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174196
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152303.2: Suppressed sequence

    Description
    NM_152303.2: This RefSeq was permanently suppressed because it contains the wrong CDS, and the correct CDS makes it a nonsense-mediated mRNA decay (NMD) candidate.
Support Center