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Adcy9 adenylate cyclase 9 [ Mus musculus (house mouse) ]

Gene ID: 11515, updated on 27-Nov-2024

Summary

Official Symbol
Adcy9provided by MGI
Official Full Name
adenylate cyclase 9provided by MGI
Primary source
MGI:MGI:108450
See related
Ensembl:ENSMUSG00000005580 AllianceGenome:MGI:108450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC9; ACtp10; D16Wsu65e; mKIAA0520
Summary
Enables adenylate cyclase activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and in utero embryonic development. Located in membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.6), ovary adult (RPKM 14.2) and 24 other tissues See more
Orthologs
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Genomic context

See Adcy9 in Genome Data Viewer
Location:
16 A1; 16 2.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4102750..4255094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4284886..4437236, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene Neighboring gene predicted gene, 36359 Neighboring gene STARR-positive B cell enhancer ABC_E4153 Neighboring gene STARR-seq mESC enhancer starr_39924 Neighboring gene tubulin cofactor a pseudogene Neighboring gene sarcalumenin Neighboring gene STARR-positive B cell enhancer mm9_chr16:4541749-4542050 Neighboring gene transcription factor AP4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adenylate cyclase type 9
Names
ATP pyrophosphate-lyase 9
adenylate cyclase type IX
adenylyl cyclase 9
adenylyl cyclase type 10
NP_001278839.1
NP_001400201.1
NP_001400202.1
NP_033754.2
XP_011244108.1
XP_036015640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291910.2NP_001278839.1  adenylate cyclase type 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2), has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC087799, AC132575
    Consensus CDS
    CCDS79418.1
    UniProtKB/TrEMBL
    E9Q706
    Related
    ENSMUSP00000113421.2, ENSMUST00000120080.8
    Conserved Domains (2) summary
    smart00044
    Location:89307
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:148336
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
  2. NM_001413272.1NP_001400201.1  adenylate cyclase type 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087799, AC132575
  3. NM_001413273.1NP_001400202.1  adenylate cyclase type 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087799, AC132575
    UniProtKB/Swiss-Prot
    P51830, Q61279
  4. NM_009624.4NP_033754.2  adenylate cyclase type 9 isoform 1

    See identical proteins and their annotated locations for NP_033754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087799, AC132575
    Consensus CDS
    CCDS27917.1
    UniProtKB/Swiss-Prot
    P51830, Q61279
    Related
    ENSMUSP00000113498.2, ENSMUST00000117801.8
    Conserved Domains (3) summary
    smart00044
    Location:326544
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:385573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam13515
    Location:142202
    FUSC_2; Fusaric acid resistance protein-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4102750..4255094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245806.2XP_011244108.1  adenylate cyclase type 9 isoform X1

    See identical proteins and their annotated locations for XP_011244108.1

    Conserved Domains (2) summary
    pfam00211
    Location:385573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl28910
    Location:134260
    MFS; Major Facilitator Superfamily
  2. XM_036159747.1XP_036015640.1  adenylate cyclase type 9 isoform X2

    Conserved Domains (2) summary
    pfam00211
    Location:385573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl28910
    Location:134260
    MFS; Major Facilitator Superfamily