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Adcy7 adenylate cyclase 7 [ Mus musculus (house mouse) ]

Gene ID: 11513, updated on 9-Mar-2023

Summary

Official Symbol
Adcy7provided by MGI
Official Full Name
adenylate cyclase 7provided by MGI
Primary source
MGI:MGI:102891
See related
Ensembl:ENSMUSG00000031659 AllianceGenome:MGI:102891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables adenylate cyclase activity. Involved in cellular response to lithium ion; negative regulation of cytokine production involved in inflammatory response; and regulation of adaptive immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 30.9), lung adult (RPKM 18.8) and 19 other tissues See more
Orthologs
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Genomic context

See Adcy7 in Genome Data Viewer
Location:
8 C3; 8 43.06 cM
Exon count:
38
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88998818..89056593)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88272190..88329965)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene terminal nucleotidyltransferase 4B Neighboring gene bromodomain containing 7 Neighboring gene predicted gene, 34751 Neighboring gene predicted gene, 39218

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141539

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cAMP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of adaptive immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
adenylate cyclase type 7
Names
ATP pyrophosphate-lyase 7
adenylate cyclase type VII
adenylyl cyclase 7
adenylyl cyclase type VII
NP_001032812.2
NP_001032813.1
NP_001103226.1
NP_031432.2
XP_006530643.1
XP_011246579.1
XP_011246580.1
XP_011246581.1
XP_011246582.1
XP_011246583.1
XP_011246584.1
XP_030099104.1
XP_036009618.1
XP_036009619.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037723.3NP_001032812.2  adenylate cyclase type 7

    See identical proteins and their annotated locations for NP_001032812.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK138911, AK155831, BB761797, BY208639
    Consensus CDS
    CCDS22509.1
    UniProtKB/Swiss-Prot
    P51829, Q3U3P2
    UniProtKB/TrEMBL
    Q3U1P1, Q3UU15
    Related
    ENSMUSP00000132528.2, ENSMUST00000171456.9
    Conserved Domains (4) summary
    smart00044
    Location:227431
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8901086
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  2. NM_001037724.4NP_001032813.1  adenylate cyclase type 7

    See identical proteins and their annotated locations for NP_001032813.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK138911, AK155831, BB761797, BY205086
    Consensus CDS
    CCDS22509.1
    UniProtKB/Swiss-Prot
    P51829, Q3U3P2
    UniProtKB/TrEMBL
    Q3U1P1, Q3UU15
    Related
    ENSMUSP00000096122.3, ENSMUST00000098521.4
    Conserved Domains (4) summary
    smart00044
    Location:227431
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8901086
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  3. NM_001109756.1NP_001103226.1  adenylate cyclase type 7

    See identical proteins and their annotated locations for NP_001103226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK138911, AK155646, AK155831, BB761797
    Consensus CDS
    CCDS22509.1
    UniProtKB/Swiss-Prot
    P51829, Q3U3P2
    UniProtKB/TrEMBL
    Q3U1P1, Q3U1X9, Q3UU15
    Related
    ENSMUSP00000129252.2, ENSMUST00000168545.8
    Conserved Domains (4) summary
    smart00044
    Location:227431
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8901086
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
  4. NM_007406.2NP_031432.2  adenylate cyclase type 7

    See identical proteins and their annotated locations for NP_031432.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC155170, AK138911, AK155831, BB761797, U12919
    Consensus CDS
    CCDS22509.1
    UniProtKB/Swiss-Prot
    P51829, Q3U3P2
    UniProtKB/TrEMBL
    Q3U1P1, Q3UU15
    Related
    ENSMUSP00000130594.2, ENSMUST00000169037.9
    Conserved Domains (4) summary
    smart00044
    Location:227431
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:8901086
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    88998818..89056593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243244.1XP_030099104.1  adenylate cyclase type 7 isoform X1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  2. XM_011248278.3XP_011246580.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011246580.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  3. XM_036153725.1XP_036009618.1  adenylate cyclase type 7 isoform X1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  4. XM_011248279.3XP_011246581.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011246581.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  5. XM_011248277.3XP_011246579.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011246579.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  6. XM_011248282.3XP_011246584.1  adenylate cyclase type 7 isoform X2

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  7. XM_036153726.1XP_036009619.1  adenylate cyclase type 7 isoform X3

    Conserved Domains (4) summary
    pfam00211
    Location:272422
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
    cl11967
    Location:890936
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
  8. XM_006530580.5XP_006530643.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_006530643.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  9. XM_011248280.1XP_011246582.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011246582.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)
  10. XM_011248281.4XP_011246583.1  adenylate cyclase type 7 isoform X1

    See identical proteins and their annotated locations for XP_011246583.1

    Conserved Domains (3) summary
    pfam00211
    Location:8901085
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:75251
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:487593
    DUF1053; Domain of Unknown Function (DUF1053)

RNA

  1. XR_878769.4 RNA Sequence

  2. XR_004934749.1 RNA Sequence