U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MARCHF3 membrane associated ring-CH-type finger 3 [ Homo sapiens (human) ]

Gene ID: 115123, updated on 3-May-2025
Official Symbol
MARCHF3provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 3provided by HGNC
Primary source
HGNC:HGNC:28728
See related
Ensembl:ENSG00000173926 MIM:613333; AllianceGenome:HGNC:28728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARCH3; RNF173; MARCH-III
Summary
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Expression
Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See MARCHF3 in Genome Data Viewer
Location:
5q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (126867714..127030558, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (127387759..127550637, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126203406..126366250, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23025 Neighboring gene RNA, U6 small nuclear 752, pseudogene Neighboring gene LMNB1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16284 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126112589-126113389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16287 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23028 Neighboring gene lamin B1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126174548-126175292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126175293-126176035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:126176780-126177522 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126181005-126181974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126183029-126183855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126211055-126211554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126231155-126231764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126366588-126367132 Neighboring gene uncharacterized LOC105379163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126376473-126377316 Neighboring gene chromosome 5 open reading frame 63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16290

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ20096, MGC48332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase MARCHF3
Names
E3 ubiquitin-protein ligase MARCH3
RING finger protein 173
RING-type E3 ubiquitin transferase MARCH3
RING-type E3 ubiquitin transferase MARCHF3
membrane associated ring finger 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
NP_848545.1
XP_011541433.1
XP_016864504.1
XP_054207529.1
XP_054207530.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033192.1 RefSeqGene

    Range
    5251..168095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178450.5NP_848545.1  E3 ubiquitin-protein ligase MARCHF3

    See identical proteins and their annotated locations for NP_848545.1

    Status: REVIEWED

    Source sequence(s)
    AC093532, AC137794, BC047569, DB455278
    Consensus CDS
    CCDS4141.1
    UniProtKB/Swiss-Prot
    A8K264, B9EJE7, Q86UD3
    Related
    ENSP00000309141.5, ENST00000308660.6
    Conserved Domains (1) summary
    cd16699
    Location:70120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    126867714..127030558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543131.4XP_011541433.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

    See identical proteins and their annotated locations for XP_011541433.1

    Conserved Domains (1) summary
    smart00744
    Location:70117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  2. XM_017009015.2XP_016864504.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    127387759..127550637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351554.1XP_054207529.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

  2. XM_054351555.1XP_054207530.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2