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MARCH3 membrane associated ring-CH-type finger 3 [ Homo sapiens (human) ]

Gene ID: 115123, updated on 17-Jun-2019

Summary

Official Symbol
MARCH3provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 3provided by HGNC
Primary source
HGNC:HGNC:28728
See related
Ensembl:ENSG00000173926 MIM:613333
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF173; MARCH-III
Summary
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Expression
Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more
Orthologs

Genomic context

See MARCH3 in Genome Data Viewer
Location:
5q23.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (126867714..127032402, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126203406..126366500, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene lamin B1 Neighboring gene Sharpr-MPRA regulatory region 3880 Neighboring gene uncharacterized LOC105379163 Neighboring gene chromosome 5 open reading frame 63 Neighboring gene mitochondrial ribosomal protein S5 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20096, MGC48332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MARCH3
Names
RING finger protein 173
RING-type E3 ubiquitin transferase MARCH3
membrane associated ring finger 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
NP_848545.1
XP_011541430.1
XP_011541431.1
XP_011541432.1
XP_011541433.1
XP_011541434.1
XP_016864503.1
XP_016864504.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033192.1 RefSeqGene

    Range
    5001..168095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178450.5NP_848545.1  E3 ubiquitin-protein ligase MARCH3

    See identical proteins and their annotated locations for NP_848545.1

    Status: REVIEWED

    Source sequence(s)
    AC093532, AC137794, BC047569, DB455278
    Consensus CDS
    CCDS4141.1
    UniProtKB/Swiss-Prot
    Q86UD3
    Related
    ENSP00000309141.5, ENST00000308660.6
    Conserved Domains (1) summary
    smart00744
    Location:70117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    126867714..127032402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543128.2XP_011541430.1  E3 ubiquitin-protein ligase MARCH3 isoform X1

  2. XM_011543130.1XP_011541432.1  E3 ubiquitin-protein ligase MARCH3 isoform X2

    See identical proteins and their annotated locations for XP_011541432.1

    Conserved Domains (1) summary
    smart00744
    Location:70117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  3. XM_017009014.1XP_016864503.1  E3 ubiquitin-protein ligase MARCH3 isoform X3

  4. XM_011543129.1XP_011541431.1  E3 ubiquitin-protein ligase MARCH3 isoform X2

    See identical proteins and their annotated locations for XP_011541431.1

    Conserved Domains (1) summary
    smart00744
    Location:70117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  5. XM_011543131.3XP_011541433.1  E3 ubiquitin-protein ligase MARCH3 isoform X2

    See identical proteins and their annotated locations for XP_011541433.1

    Conserved Domains (1) summary
    smart00744
    Location:70117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  6. XM_017009015.1XP_016864504.1  E3 ubiquitin-protein ligase MARCH3 isoform X5

  7. XM_011543132.1XP_011541434.1  E3 ubiquitin-protein ligase MARCH3 isoform X4

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