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MARCHF3 membrane associated ring-CH-type finger 3 [ Homo sapiens (human) ]

Gene ID: 115123, updated on 7-Sep-2023

Summary

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Official Symbol
MARCHF3provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 3provided by HGNC
Primary source
HGNC:HGNC:28728
See related
Ensembl:ENSG00000173926 MIM:613333; AllianceGenome:HGNC:28728
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARCH3; RNF173; MARCH-III
Summary
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]
Expression
Broad expression in testis (RPKM 2.7), heart (RPKM 1.5) and 22 other tissues See more
Orthologs
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Genomic context

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See MARCHF3 in Genome Data Viewer
Location:
5q23.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (126867714..127030558, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (127387759..127550637, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (126203406..126366250, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 752, pseudogene Neighboring gene LMNB1 divergent transcript Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126112589-126113389 Neighboring gene lamin B1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126174548-126175292 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126175293-126176035 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:126176780-126177522 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126181005-126181974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126183029-126183855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126211055-126211554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:126231155-126231764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:126366588-126367132 Neighboring gene uncharacterized LOC105379163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:126376473-126377316 Neighboring gene chromosome 5 open reading frame 63

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase MARCH3 controls the endothelial barrier. Leclair HM, et al. FEBS Lett, 2016 Oct. PMID 27616439, Free PMC Article
  2. Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination. Fatehchand K, et al. J Biol Chem, 2016 Feb 19. PMID 26694610, Free PMC Article
  3. MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Feng L, et al. Signal Transduct Target Ther, 2022 Jan 24. PMID 35075102, Free PMC Article
  4. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. Fukuda H, et al. J Biochem, 2006 Jan. PMID 16428329
  5. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.
    Title: RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma.
  2. Report shows that silencing MARCH3 protects the endothelial barrier and upregulates OCLN in MARCH3-depleted cells. MARCH3 silencing results in the strengthening of cell-cell contacts and inactivates FoxO1.
    Title: The E3 ubiquitin ligase MARCH3 controls the endothelial barrier.
  3. LPS activation of TLR4 significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS treatment.
    Title: Toll-like Receptor 4 Ligands Down-regulate Fcγ Receptor IIb (FcγRIIb) via MARCH3 Protein-mediated Ubiquitination.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20096, MGC48332

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF3
Names
E3 ubiquitin-protein ligase MARCH3
RING finger protein 173
RING-type E3 ubiquitin transferase MARCH3
RING-type E3 ubiquitin transferase MARCHF3
membrane associated ring finger 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
NP_848545.1
XP_011541433.1
XP_016864504.1
XP_054207529.1
XP_054207530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033192.1 RefSeqGene

    Range
    5251..168095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178450.5 → NP_848545.1  E3 ubiquitin-protein ligase MARCHF3

    See identical proteins and their annotated locations for NP_848545.1

    Status: REVIEWED

    Source sequence(s)
    AC093532, AC137794, BC047569, DB455278
    Consensus CDS
    CCDS4141.1
    UniProtKB/Swiss-Prot
    A8K264, B9EJE7, Q86UD3
    Related
    ENSP00000309141.5, ENST00000308660.6
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    126867714..127030558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543131.4 → XP_011541433.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

    See identical proteins and their annotated locations for XP_011541433.1

    Conserved Domains (1) summary
    smart00744
    Location:70 → 117
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

  2. XM_017009015.2 → XP_016864504.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    127387759..127550637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351554.1 → XP_054207529.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

  2. XM_054351555.1 → XP_054207530.1  E3 ubiquitin-protein ligase MARCHF3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UD3.1 GenPept UniProtKB/Swiss-Prot:Q86UD3

Gene LinkOut

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