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SLC26A7 solute carrier family 26 member 7 [ Homo sapiens (human) ]

Gene ID: 115111, updated on 17-Jun-2019

Summary

Official Symbol
SLC26A7provided by HGNC
Official Full Name
solute carrier family 26 member 7provided by HGNC
Primary source
HGNC:HGNC:14467
See related
Ensembl:ENSG00000147606 MIM:608479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUT2
Summary
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Aug 2013]
Expression
Restricted expression toward thyroid (RPKM 194.6) See more
Orthologs

Genomic context

See SLC26A7 in Genome Data Viewer
Location:
8q21.3
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (91209496..91398155)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (92261508..92410378)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 69 Neighboring gene ceruloplasmin pseudogene Neighboring gene microRNA 4661 Neighboring gene uncharacterized LOC105375637 Neighboring gene VISTA enhancer hs1601 Neighboring gene RN7SK pseudogene 231

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: LRRC69

Homology

Clone Names

  • MGC126268

Gene Ontology Provided by GOA

Function Evidence Code Pubs
anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicarbonate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
anion transport IDA
Inferred from Direct Assay
more info
PubMed 
bicarbonate transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
oxalate transport IDA
Inferred from Direct Assay
more info
PubMed 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
anion exchange transporter
Names
solute carrier family 26 (anion exchanger), member 7
sulfate anion transporter

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282356.2NP_001269285.1  anion exchange transporter isoform a

    See identical proteins and their annotated locations for NP_001269285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AF331521, AI758950, BC094730
    Consensus CDS
    CCDS6254.1
    UniProtKB/Swiss-Prot
    Q8TE54
    Related
    ENSP00000428849.1, ENST00000523719.5
    Conserved Domains (2) summary
    cd07042
    Location:495631
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33637
    sulP; high affinity sulphate transporter 1
  2. NM_001282357.2NP_001269286.1  anion exchange transporter isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 3. This variant represents translation initiation at a downstream AUG; the 5'-most initiation codon, as used in variant 3, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode isoform c.
    Source sequence(s)
    AF331521, AI758950, BC060784, BC094730
    Consensus CDS
    CCDS75765.1
    UniProtKB/Swiss-Prot
    Q8TE54
    UniProtKB/TrEMBL
    A0A087WZI7
    Related
    ENSP00000482686.1, ENST00000617078.3
    Conserved Domains (2) summary
    cd07042
    Location:194330
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:2336
    sulP; high affinity sulphate transporter 1
  3. NM_052832.4NP_439897.1  anion exchange transporter isoform a

    See identical proteins and their annotated locations for NP_439897.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AF331521, AI758950, AJ413229, BC094730
    Consensus CDS
    CCDS6254.1
    UniProtKB/Swiss-Prot
    Q8TE54
    Related
    ENSP00000276609.3, ENST00000276609.8
    Conserved Domains (2) summary
    cd07042
    Location:495631
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33637
    sulP; high affinity sulphate transporter 1
  4. NM_134266.2NP_599028.1  anion exchange transporter isoform b

    See identical proteins and their annotated locations for NP_599028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate terminal exon, which results in a frameshift, compared to variant 3. The resulting isoform (b) has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC087847, AC104967
    Consensus CDS
    CCDS6255.1
    UniProtKB/Swiss-Prot
    Q8TE54
    Related
    ENSP00000309504.2, ENST00000309536.6
    Conserved Domains (2) summary
    cd07042
    Location:495631
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:33637
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    91209496..91398155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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