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HAUS1 HAUS augmin like complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 115106, updated on 29-Mar-2020

Summary

Official Symbol
HAUS1provided by HGNC
Official Full Name
HAUS augmin like complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:25174
See related
Ensembl:ENSG00000152240 MIM:608775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HEIC; CCDC5; HEI-C; HsT1461
Summary
HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Expression
Ubiquitous expression in lymph node (RPKM 14.6), bone marrow (RPKM 12.1) and 25 other tissues See more
Orthologs

Genomic context

See HAUS1 in Genome Data Viewer
Location:
18q21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (46104385..46128333)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (43684298..43708299)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (CTT) 6-1 Neighboring gene RNY4 pseudogene 37 Neighboring gene ATP synthase F1 subunit alpha Neighboring gene RNA, U6 small nuclear 1278, pseudogene Neighboring gene chromosome 18 open reading frame 25 Neighboring gene ring finger protein 165 Neighboring gene uncharacterized LOC105372095

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21094, FLJ40084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 1
Names
coiled-coil domain containing 5 (spindle associated)
coiled-coil domain-containing protein 5
enhancer of invasion-cluster

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138443.4NP_612452.1  HAUS augmin-like complex subunit 1

    See identical proteins and their annotated locations for NP_612452.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and is protein-coding.
    Source sequence(s)
    BC014003
    Consensus CDS
    CCDS11928.1
    UniProtKB/Swiss-Prot
    Q96CS2
    Related
    ENSP00000282058.5, ENST00000282058.11
    Conserved Domains (1) summary
    cl25632
    Location:168270
    type_I_hlyD; type I secretion membrane fusion protein, HlyD family

RNA

  1. NR_026978.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY360137, BC005958, BC014003
    Related
    ENST00000591715.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    46104385..46128333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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