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SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough [ Homo sapiens (human) ]

Gene ID: 115072896, updated on 24-Dec-2022

Summary

Official Symbol
SLCO1B3-SLCO1B7provided by HGNC
Official Full Name
SLCO1B3-SLCO1B7 readthroughprovided by HGNC
Primary source
HGNC:HGNC:54403
See related
Ensembl:ENSG00000257046 AllianceGenome:HGNC:54403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LST-3TM12; OATP1B3-1B7
Summary
This locus represents naturally occurring readthrough transcription between the neighboring SLCO1B3 (solute carrier organic anion transporter family member 1B3) and SLCO1B7 (solute carrier organic anion transporter family member 1B7 (putative)) genes on chromosome 12. The readthrough transcript encodes a protein that shares sequence identity with both the upstream and downstream genes. [provided by RefSeq, Jun 2019]
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Genomic context

See SLCO1B3-SLCO1B7 in Genome Data Viewer
Location:
12p12.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (20815674..21091222)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (20694298..20969842)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (20968608..21244156)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 3A Neighboring gene ubiquitin like with PHD and ring finger domains 1 pseudogene Neighboring gene solute carrier organic anion transporter family member 1C1 Neighboring gene solute carrier organic anion transporter family member 1B3 Neighboring gene putative solute carrier organic anion transporter family member 1B7 Neighboring gene solute carrier organic anion transporter family member 1B1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC124902895

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in smooth endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SLCO1B3-SLCO1B7 readthrough transcript protein
Names
liver specific transporter-3 transmembrane 12
organic anion transporting polypeptide 1B3-1B7
solute carrier organic anion transporter family member 1B3-1B7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371097.1NP_001358026.1  SLCO1B3-SLCO1B7 readthrough transcript protein

    Status: VALIDATED

    Source sequence(s)
    AC011604, AC087309, AY442326
    UniProtKB/TrEMBL
    A0A0A6YYJ9
    Related
    ENSP00000441269.1, ENST00000540229.1
    Conserved Domains (1) summary
    cl28910
    Location:28561
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    20815674..21091222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    20694298..20969842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)