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Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 [ Mus musculus (house mouse) ]

Gene ID: 11504, updated on 27-Feb-2024

Summary

Official Symbol
Adamts1provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 1provided by MGI
Primary source
MGI:MGI:109249
See related
Ensembl:ENSMUSG00000022893 AllianceGenome:MGI:109249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
Expression
Broad expression in lung adult (RPKM 22.1), subcutaneous fat pad adult (RPKM 15.6) and 23 other tissues See more
Orthologs
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Genomic context

See Adamts1 in Genome Data Viewer
Location:
16 C3.3; 16 48.2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (85590715..85600001, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (85793827..85803113, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52244 Neighboring gene STARR-seq mESC enhancer starr_41383 Neighboring gene STARR-seq mESC enhancer starr_41384 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41385 Neighboring gene STARR-seq mESC enhancer starr_41386 Neighboring gene STARR-seq mESC enhancer starr_41388 Neighboring gene STARR-seq mESC enhancer starr_41389 Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 5 Neighboring gene STARR-seq mESC enhancer starr_41390 Neighboring gene predicted gene, 46558

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metalloendopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 1
Names
ADAM-TS 1
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
NP_033751.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009621.5NP_033751.3  A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein

    See identical proteins and their annotated locations for NP_033751.3

    Status: REVIEWED

    Source sequence(s)
    AC126936, AK161409, AK163622, BP764139, CF738767
    Consensus CDS
    CCDS28287.1
    UniProtKB/Swiss-Prot
    E9QMN9, O54768, P97857
    UniProtKB/TrEMBL
    Q3U0I4
    Related
    ENSMUSP00000023610.9, ENSMUST00000023610.15
    Conserved Domains (6) summary
    smart00209
    Location:563615
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:259464
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:259468
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:70194
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:726843
    ADAM_spacer1; ADAM-TS Spacer 1
    cl15456
    Location:469549
    ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    85590715..85600001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)