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SLC26A9 solute carrier family 26 member 9 [ Homo sapiens (human) ]

Gene ID: 115019, updated on 23-Nov-2021

Summary

Official Symbol
SLC26A9provided by HGNC
Official Full Name
solute carrier family 26 member 9provided by HGNC
Primary source
HGNC:HGNC:14469
See related
Ensembl:ENSG00000174502 MIM:608481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.[provided by RefSeq, Dec 2008]
Expression
Biased expression in salivary gland (RPKM 19.0), stomach (RPKM 12.3) and 5 other tissues See more
Orthologs
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Genomic context

See SLC26A9 in Genome Data Viewer
Location:
1q32.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (205913048..205943472, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205882180..205912584, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985250 Neighboring gene peptidase M20 domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 4160 Neighboring gene uncharacterized LOC284581 Neighboring gene SLC26A9 and RAB7B antisense RNA 1 Neighboring gene uncharacterized LOC103021295 Neighboring gene RAB7B, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
GeneReviews: Not available
Genetic modifiers of cystic fibrosis-related diabetes.
GeneReviews: Not available
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables anion:anion antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables anion:anion antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chloride channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chloride channel activity TAS
Traceable Author Statement
more info
 
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in anion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bicarbonate transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ion transport TAS
Traceable Author Statement
more info
 
involved_in oxalate transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 26 member 9
Names
anion transporter/exchanger protein 9
anion transporter/exchanger-9
solute carrier family 26 (anion exchanger), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052934.4NP_443166.1  solute carrier family 26 member 9 isoform a

    See identical proteins and their annotated locations for NP_443166.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes isoform a.
    Source sequence(s)
    AF314958, AF331525, BC037978
    Consensus CDS
    CCDS30990.1
    UniProtKB/Swiss-Prot
    Q7LBE3
    Related
    ENSP00000356103.3, ENST00000367135.8
    Conserved Domains (2) summary
    cd07042
    Location:662730
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:57561
    sulP; high affinity sulphate transporter 1
  2. NM_134325.3NP_599152.2  solute carrier family 26 member 9 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal segment of sequence, compared to variant 1, which causes a frameshift. It encodes a protein (isoform b) with a longer C-terminus than isoform a.
    Source sequence(s)
    AF314958, AF331525, AK127491
    Consensus CDS
    CCDS30989.1
    UniProtKB/Swiss-Prot
    Q7LBE3
    UniProtKB/TrEMBL
    B3KXK1
    Related
    ENSP00000356102.2, ENST00000367134.2
    Conserved Domains (2) summary
    cd07042
    Location:662730
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:74468
    Sulfate_transp; Sulfate permease family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    205913048..205943472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509121.2XP_011507423.1  solute carrier family 26 member 9 isoform X1

    Conserved Domains (2) summary
    cd07042
    Location:573641
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:1379
    Sulfate_transp; Sulfate permease family
  2. XM_011509122.2XP_011507424.1  solute carrier family 26 member 9 isoform X2

    Conserved Domains (2) summary
    cd07042
    Location:498566
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:8397
    sulP; high affinity sulphate transporter 1
  3. XM_011509124.2XP_011507426.1  solute carrier family 26 member 9 isoform X3

    Conserved Domains (1) summary
    pfam00916
    Location:74466
    Sulfate_transp; Sulfate permease family

RNA

  1. XR_001736957.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001142600.1: Suppressed sequence

    Description
    NM_001142600.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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