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Adam8 a disintegrin and metallopeptidase domain 8 [ Mus musculus (house mouse) ]

Gene ID: 11501, updated on 18-Apr-2024

Summary

Official Symbol
Adam8provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 8provided by MGI
Primary source
MGI:MGI:107825
See related
Ensembl:ENSMUSG00000025473 AllianceGenome:MGI:107825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MS2; CD156; ADAM 8; CD156a; E430039A18Rik
Summary
This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]
Expression
Broad expression in ovary adult (RPKM 21.0), thymus adult (RPKM 6.6) and 19 other tissues See more
Orthologs
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Genomic context

Location:
7 F4; 7 84.96 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139558845..139573016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139978932..139995207, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene microRNA 202 Neighboring gene STARR-positive B cell enhancer ABC_E10482 Neighboring gene STARR-positive B cell enhancer ABC_E11374 Neighboring gene sperm flagellar 1 like Neighboring gene STARR-seq mESC enhancer starr_20441 Neighboring gene microRNA 7062 Neighboring gene tubulin, gamma complex component 2 Neighboring gene STARR-seq mESC enhancer starr_20442 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511 Neighboring gene msh homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding TAS
Traceable Author Statement
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood vessel endothelial cell migration NAS
Non-traceable Author Statement
more info
PubMed 
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane fusion TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of thymocyte aggregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in osteoclast fusion TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of acute inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular extravasation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of eosinophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibronectin-dependent thymocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of osteoclast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in tissue morphogenesis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of alpha9-beta1 integrin-ADAM8 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagolysosome ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in podosome ISO
Inferred from Sequence Orthology
more info
 
located_in podosome TAS
Traceable Author Statement
more info
PubMed 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 
located_in tertiary granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 8
Names
a disintegrin and metalloprotease domain 8
cell surface antigen MS2
macrophage cysteine-rich glycoprotein
NP_001277995.1
NP_031429.1
XP_006536214.1
XP_017177421.1
XP_017177422.1
XP_017177423.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291066.3NP_001277995.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001277995.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice acceptor site compared to variant 1. It encodes a protein (isoform 2) that is slightly shorter than isoform 1.
    Source sequence(s)
    AC107822
    Consensus CDS
    CCDS72064.1
    UniProtKB/TrEMBL
    Q3TVN5, Q3U1R3, Q3U6N3, Q3U7G2, Q8R3D3
    Related
    ENSMUSP00000026546.10, ENSMUST00000026546.16
    Conserved Domains (5) summary
    smart00050
    Location:411485
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:487606
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:195392
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:195394
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:49148
    Pep_M12B_propep; Reprolysin family propeptide
  2. NM_007403.4NP_031429.1  disintegrin and metalloproteinase domain-containing protein 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein isoform (1).
    Source sequence(s)
    AC107822
    Consensus CDS
    CCDS21959.1
    UniProtKB/Swiss-Prot
    Q05910
    UniProtKB/TrEMBL
    Q3TVN5, Q3U1J7, Q3U1R3, Q3U6N3, Q8R3D3
    Related
    ENSMUSP00000101684.3, ENSMUST00000106069.9
    Conserved Domains (5) summary
    smart00050
    Location:412486
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:488607
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:196393
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:196395
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:50149
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    139558845..139573016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321933.3XP_017177422.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X2

    UniProtKB/TrEMBL
    Q3TVN5, Q3U1R3, Q3U6N3, Q8R3D3
    Conserved Domains (6) summary
    smart00050
    Location:411485
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:487606
    ACR; ADAM Cysteine-Rich Domain
    PHA03247
    Location:637856
    PHA03247; large tegument protein UL36; Provisional
    pfam01421
    Location:195394
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:27151
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05104
    Location:770855
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
  2. XM_006536151.4XP_006536214.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X3

    UniProtKB/TrEMBL
    Q3TVN5, Q3U1R3, Q3U6N3, Q8R3D3
    Conserved Domains (5) summary
    smart00050
    Location:412486
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:488607
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:196395
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:28152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05104
    Location:766851
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
  3. XM_017321932.3XP_017177421.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X1

    UniProtKB/TrEMBL
    Q3TVN5, Q3U1R3, Q3U6N3, Q8R3D3
    Conserved Domains (6) summary
    smart00050
    Location:412486
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:488607
    ACR; ADAM Cysteine-Rich Domain
    PHA03247
    Location:638857
    PHA03247; large tegument protein UL36; Provisional
    pfam01421
    Location:196395
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:28152
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05104
    Location:771856
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
  4. XM_017321934.3XP_017177423.1  disintegrin and metalloproteinase domain-containing protein 8 isoform X4

    UniProtKB/TrEMBL
    E9Q359, Q8C269
    Related
    ENSMUSP00000117858.2, ENSMUST00000148670.8
    Conserved Domains (4) summary
    smart00050
    Location:412486
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:488607
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:196395
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:28152
    Pep_M12B_propep; Reprolysin family propeptide